NP_036312.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box only protein 8
NCBI Official Synonym Full Names
F-box protein 8
NCBI Protein Information
F-box only protein 8; F-box protein Fbx8; F-box/SEC7 protein FBS
UniProt Protein Name
F-box only protein 8
UniProt Synonym Protein Names
F-box/SEC7 protein FBS
UniProt Synonym Gene Names
UniProt Entry Name
FBX8_HUMAN
NCBI Summary for FBXO8
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
UniProt Comments for FBXO8
FBXO8: an F-box protein that apparently mediates the ubiquitination of Arf6. May function as a guanine nucleotide exchange factor (GEF) that activates ARF G proteins. The loss of FBXO8 correlates with poor survival in hepatocellular carcinoma.
Protein type: GEFs, ARF; Ubiquitin conjugating system; GEFs
Chromosomal Location of Human Ortholog: 4q34.1
Cellular Component: trans-Golgi network; nucleus; cell junction; ubiquitin ligase complex
Molecular Function: ARF guanyl-nucleotide exchange factor activity
Biological Process: vesicle-mediated transport; ubiquitin-dependent protein catabolic process; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
Research Articles on FBXO8
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Pathways associated with FBXO8 elisa kit
Diseases associated with FBXO8 elisa kit
Organs/Tissues associated with FBXO8 elisa kit
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