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FBN1 elisa kit :: Human FBN1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2502651
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FBN1, ELISA Kit

★Popular Item★
 Also Known As   

Human FBN1 (Fibrillin 1) ELISA Kit

 Product Gene Name   

FBN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2502651 COA    COA PDF
 MBS2502651 Testing Data    Testing Data PDF
 OMIM    102370
 3D Structure    ModBase 3D Structure for P35555
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and some recombinant Human FBN1. No significant crossreactivity or interference between Human FBN1 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.313-20ng/mL
 Sensitivity    Min: 0.188ng/mL; Max: 20ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FBN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FBN1 purchase    MBS2502651 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FBN1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313-20ng/mL in biological research samples containing FBN1, with an estimated sensitivity of Min: 0.188ng/mL; Max: 20ng/mL. The ELISA analytical biochemical technique of the MBS2502651 kit is based on FBN1 antibody-FBN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FBN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FBN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FBN1 elisa kit

   Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Human FBN1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Human FBN1. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Human FBN1 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human FBN1, biotinylated detection antibody and Avidin- HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human FBN1. The concentration of Human FBN1 in samples can be calculated by comparing the OD of the samples with the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of FBN1 elisa kit    FBN1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2502651. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FBN1. It may not necessarily be applicable to this product.
 NCBI GI #    281485550
 NCBI GeneID    2200
 NCBI Accession #    NP_000129.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000138.4 [Other Products]
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 UniProt Primary Accession #    P35555 [Other Products]
 UniProt Secondary Accession #    Q15972; Q75N87; B2RUU0; D2JYH6 [Other Products]
 UniProt Related Accession #    P35555 [Other Products]
 Molecular Weight    312,237 Da
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 NCBI Official Full Name    fibrillin-1
 NCBI Official Synonym Full Names    fibrillin 1
 NCBI Official Symbol    FBN1 [Similar Products]
 NCBI Official Synonym Symbols   
FBN; SGS; WMS; MASS; MFS1; OCTD; SSKS; WMS2; ACMICD; ECTOL1; GPHYSD2
[Similar Products]
 NCBI Protein Information    fibrillin-1; fibrillin 15
 UniProt Protein Name    Fibrillin-1
 Protein Family    Fibrillin
 UniProt Gene Name    FBN1 [Similar Products]
 UniProt Synonym Gene Names    FBN [Similar Products]
 UniProt Entry Name    FBN1_HUMAN
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 NCBI Summary for FBN1    This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBN1    FBN1: a large, extracellular matrix glycoprotein of the fibrillin family that serves as a structural component of 10-12 nm calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support in elastic and nonelastic connective tissue throughout the body. May regulate osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Defects in this protein are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome. Interacts with COL16A1.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region; microfibril; basement membrane

Molecular Function: protein binding; extracellular matrix structural constituent; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; heart development; metanephros development; skeletal development

Disease: Ectopia Lentis 1, Isolated, Autosomal Dominant; Mass Syndrome; Weill-marchesani Syndrome 2; Acromicric Dysplasia; Stiff Skin Syndrome; Marfan Syndrome; Geleophysic Dysplasia 2
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 Research Articles on FBN1    1. Identification of single nucleotide polymorphisms of FBN1 gene that are associated with essential hypertension in Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBN1 elisa kitPathways associated with FBN1 elisa kit
 Reference Product  PubMed Publications
 DCN elisa kit  >4 publications with FBN1 and DCN
 ELN elisa kit  >4 publications with FBN1 and ELN
 FBLN2 elisa kit  >2 publications with FBN1 and FBLN2
 ITGA5 elisa kit  >1 publications with FBN1 and ITGA5
 ITGB6 elisa kit  >1 publications with FBN1 and ITGB6
 ITGAV elisa kit  >1 publications with FBN1 and ITGAV
 MFAP5 elisa kit  >1 publications with FBN1 and MFAP5
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
Diseases associated with FBN1 elisa kitOrgans/Tissues associated with FBN1 elisa kit
 Disease Name  Pubmed Publications
 Marfan Syndrome Antibodies  >470 publications with FBN1 and Marfan Syndrome
 Cardiovascular Diseases Antibodies  >411 publications with FBN1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >387 publications with FBN1 and Heart Diseases
 Ectopia Lentis Antibodies  >93 publications with FBN1 and Ectopia Lentis
 Aortic Aneurysm, Thoracic Antibodies  >61 publications with FBN1 and Aortic Aneurysm, Thoracic
 Disease Models, Animal Antibodies  >41 publications with FBN1 and Disease Models, Animal
 Arachnodactyly Antibodies  >35 publications with FBN1 and Arachnodactyly
 Aortic Rupture Antibodies  >25 publications with FBN1 and Aortic Rupture
 Nervous System Diseases Antibodies  >20 publications with FBN1 and Nervous System Diseases
 Weill-Marchesani Syndrome Antibodies  >17 publications with FBN1 and Weill-Marchesani Syndrome
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >217 publications with FBN1 and Connective Tissue
 Vascular Antibodies  >88 publications with FBN1 and Vascular
 Heart Antibodies  >66 publications with FBN1 and Heart
 Skin Antibodies  >63 publications with FBN1 and Skin
 Eye Antibodies  >42 publications with FBN1 and Eye
 Muscle Antibodies  >40 publications with FBN1 and Muscle
 Lung Antibodies  >18 publications with FBN1 and Lung
 Embryonic Tissue Antibodies  >14 publications with FBN1 and Embryonic Tissue
 Kidney Antibodies  >10 publications with FBN1 and Kidney
 Brain Antibodies  >6 publications with FBN1 and Brain
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