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FGFR1 elisa kit :: Human FGFR1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2515536
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FGFR1, ELISA Kit

★Popular Item★
 Also Known As   

Human FGFR1 (Fibroblast Growth Factor Receptor 1) ELISA Kit

 Product Gene Name   

FGFR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2515536 COA    COA PDF
 OMIM    101600
 3D Structure    ModBase 3D Structure for P11362
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human FGFR1. No significant cross-reactivity or interference between Human FGFR1 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human FGFR1 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156--10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FGFR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FGFR1 purchase    MBS2515536 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FGFR1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156--10ng/mL in biological research samples containing FGFR1, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2515536 kit is based on FGFR1 antibody-FGFR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FGFR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FGFR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FGFR1 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FGFR1 in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human FGFR1. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human FGFR1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human FGFR1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human FGFR1. You can calculate the concentration of Human FGFR1 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of FGFR1 elisa kit    FGFR1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2515536. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FGFR1. It may not necessarily be applicable to this product.
 NCBI GI #    105990522
 NCBI GeneID    2260
 NCBI Accession #    NP_075598.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_023110.2 [Other Products]
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 UniProt Primary Accession #    P11362 [Other Products]
 UniProt Secondary Accession #    P17049; Q02063; Q02065; Q14306; Q14307; Q53H63; Q59H40; Q5BJG2; A8K6T9; A8K8V5; C1KBH8 [Other Products]
 UniProt Related Accession #    P11362 [Other Products]
 Molecular Weight    95,344 Da
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 NCBI Official Full Name    fibroblast growth factor receptor 1 isoform 1
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 1
 NCBI Official Symbol    FGFR1 [Similar Products]
 NCBI Official Synonym Symbols   
CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 1; FGFR1/PLAG1 fusion; FMS-like tyrosine kinase 2; basic fibroblast growth factor receptor 1; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; proto-oncogene c-Fgr
 UniProt Protein Name    Fibroblast growth factor receptor 1
 UniProt Synonym Protein Names   
Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD_antigen: CD331
 Protein Family    FGFR1 oncogene partner
 UniProt Gene Name    FGFR1 [Similar Products]
 UniProt Synonym Gene Names    BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; FGFR-1; BFGFR; bFGF-R-1; FLT-2 [Similar Products]
 UniProt Entry Name    FGFR1_HUMAN
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 NCBI Summary for FGFR1    The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGFR1    FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Membrane protein, integral; Oncoprotein; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; FGFR family

Chromosomal Location of Human Ortholog: 8p11.23-p11.22

Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane; extracellular region; cytosol; nucleus; receptor complex

Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding

Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; regulation of cell differentiation; positive regulation of mesenchymal cell proliferation; midbrain development; positive regulation of cell proliferation; chondrocyte differentiation; angiogenesis; skeletal development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; cell migration; inner ear morphogenesis; chordate embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; neuroblast division in the ventricular zone; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; innate immune response; auditory receptor cell development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification

Disease: Pfeiffer Syndrome; Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Trigonocephaly 1; Osteoglophonic Dysplasia
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 Research Articles on FGFR1    1. Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FGFR1 elisa kitDiseases associated with FGFR1 elisa kit
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >138 publications with FGFR1 and Nervous System Diseases
 Myeloproliferative Disorders Antibodies  >136 publications with FGFR1 and Myeloproliferative Disorders
 Disease Models, Animal Antibodies  >130 publications with FGFR1 and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >129 publications with FGFR1 and Craniofacial Abnormalities
 Kallmann Syndrome Antibodies  >125 publications with FGFR1 and Kallmann Syndrome
 Breast Neoplasms Antibodies  >107 publications with FGFR1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >85 publications with FGFR1 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >68 publications with FGFR1 and Carcinoma, Squamous Cell
 TRIGONOCEPHALY 1 Antibodies  >68 publications with FGFR1 and TRIGONOCEPHALY 1
 Neoplasms, Experimental Antibodies  >61 publications with FGFR1 and Neoplasms, Experimental
Organs/Tissues associated with FGFR1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >332 publications with FGFR1 and Vascular
 Brain Antibodies  >330 publications with FGFR1 and Brain
 Blood Antibodies  >325 publications with FGFR1 and Blood
 Bone Antibodies  >311 publications with FGFR1 and Bone
 Embryonic Tissue Antibodies  >222 publications with FGFR1 and Embryonic Tissue
 Nerve Antibodies  >213 publications with FGFR1 and Nerve
 Muscle Antibodies  >205 publications with FGFR1 and Muscle
 Lung Antibodies  >163 publications with FGFR1 and Lung
 Kidney Antibodies  >103 publications with FGFR1 and Kidney
 Bone Marrow Antibodies  >96 publications with FGFR1 and Bone Marrow
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