NP_004454.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,561 Da
NCBI Official Full Name
FYVE, RhoGEF and PH domain-containing protein 1
NCBI Official Synonym Full Names
FYVE, RhoGEF and PH domain containing 1
NCBI Protein Information
FYVE, RhoGEF and PH domain-containing protein 1; rho/Rac GEF; faciogenital dysplasia 1 protein; zinc finger FYVE domain-containing protein 3; rho/Rac guanine nucleotide exchange factor FGD1
UniProt Protein Name
FYVE, RhoGEF and PH domain-containing protein 1
UniProt Synonym Protein Names
Faciogenital dysplasia 1 protein; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF; Zinc finger FYVE domain-containing protein 3
UniProt Synonym Gene Names
UniProt Entry Name
FGD1_HUMAN
NCBI Summary for FGD1
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011]
UniProt Comments for FGD1
FGD1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1. Binds CDC42. Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Protein type: GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: ruffle; Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; cytosol
Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding
Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; organ morphogenesis; filopodium formation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; signal transduction; positive regulation of GTPase activity
Disease: Aarskog-scott Syndrome
Research Articles on FGD1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with FGD1 elisa kit
Pathways associated with FGD1 elisa kit
Diseases associated with FGD1 elisa kit
Organs/Tissues associated with FGD1 elisa kit
|