NP_001991.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,265 Da
NCBI Official Full Name
immunoglobulin alpha Fc receptor isoform a
NCBI Official Synonym Full Names
Fc fragment of IgA, receptor for
NCBI Official Synonym Symbols
NCBI Protein Information
immunoglobulin alpha Fc receptor; IgA Fc receptor; Fc alpha receptor
UniProt Protein Name
Immunoglobulin alpha Fc receptor
UniProt Synonym Protein Names
CD_antigen: CD89
UniProt Synonym Gene Names
UniProt Entry Name
FCAR_HUMAN
NCBI Summary for FCAR
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FCAR
FCAR: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: IgA binding
Biological Process: immune response
Research Articles on FCAR
Precautions
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Disclaimer
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Pathways associated with FCAR elisa kit
Diseases associated with FCAR elisa kit
Organs/Tissues associated with FCAR elisa kit
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