EAW74001.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,226 Da
NCBI Official Full Name
ferritin, heavy polypeptide 1, isoform CRA_a
NCBI Official Synonym Full Names
ferritin, heavy polypeptide 1
NCBI Official Synonym Symbols
FHC; FTH; HFE5; PLIF; FTHL6; PIG15 [Similar Products]
NCBI Protein Information
ferritin heavy chain; apoferritin; ferritin H subunit; placenta immunoregulatory factor; proliferation-inducing protein 15; cell proliferation-inducing gene 15 protein
UniProt Protein Name
Ferritin heavy chain
UniProt Synonym Protein Names
Cell proliferation-inducing gene 15 proteinCleaved into the following chain:Ferritin heavy chain, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
FRIH_HUMAN
NCBI Summary for FTH
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for FTH
Ferritin-H: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family.
Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: ferritin complex; mitochondrion; cytosol; nucleus
Molecular Function: ferroxidase activity; protein binding; ferric iron binding; iron ion binding
Biological Process: receptor-mediated endocytosis; negative regulation of cell proliferation; cellular iron ion homeostasis; negative regulation of fibroblast proliferation; immune response; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport; intracellular sequestering of iron ion
Disease: Hemochromatosis, Type 5
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Products associated with FTH elisa kit
Pathways associated with FTH elisa kit
Diseases associated with FTH elisa kit
Organs/Tissues associated with FTH elisa kit
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