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GNalphaI3 elisa kit :: Human G Protein Alpha Inhibiting Activity Polypeptide 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS063348 GNalphaI3 elisa kit
Unit / Price
48-Strip-Wells  /  $500 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,250 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,395 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G Protein Alpha Inhibiting Activity Polypeptide 3 (GNalphaI3), ELISA Kit

 Also Known As   

Human G Protein Alpha Inhibiting Activity Polypeptide 3 ELISA Kit

 Product Gene Name   

GNalphaI3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    139370
 3D Structure    ModBase 3D Structure for P08754
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GNalphaI3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GNalphaI3 purchase    MBS063348 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G Protein Alpha Inhibiting Activity Polypeptide 3 (GNalphaI3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GNalphaI3. The ELISA analytical biochemical technique of the MBS063348 kit is based on GNalphaI3 antibody-GNalphaI3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GNalphaI3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GNalphaI3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GNalphaI3. It may not necessarily be applicable to this product.
 NCBI GI #    119576797
 NCBI GeneID    2773
 NCBI Accession #    EAW56393.1 [Other Products]
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 UniProt Primary Accession #    P08754 [Other Products]
 UniProt Secondary Accession #    P17539; Q5TZX1 [Other Products]
 UniProt Related Accession #    P08754 [Other Products]
 Molecular Weight    40,532 Da
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 NCBI Official Full Name    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
 NCBI Official Synonym Full Names    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
 NCBI Official Symbol    GNAI3 [Similar Products]
 NCBI Official Synonym Symbols   
87U6; ARCND1
[Similar Products]
 NCBI Protein Information    guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; g(i) alpha-3
 UniProt Protein Name    Guanine nucleotide-binding protein G(k) subunit alpha
 UniProt Synonym Protein Names   
G(i) alpha-3
 UniProt Gene Name    GNAI3 [Similar Products]
 UniProt Entry Name    GNAI3_HUMAN
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 NCBI Summary for GNalphaI3    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
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 UniProt Comments for GNalphaI3    G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric; G protein

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: Golgi apparatus; centrosome; membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft

Molecular Function: GTPase activity; protein domain specific binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding

Biological Process: vesicle fusion; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; platelet activation; cell division; metabolic process; transport; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; cell cycle

Disease: Auriculocondylar Syndrome 1
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 Research Articles on GNalphaI3    1. Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN/nuclear mitotic apparatus (NuMA) complex from cell cortex to spindle poles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GNalphaI3 elisa kitPathways associated with GNalphaI3 elisa kit
 Reference Product  PubMed Publications
 RGS19 elisa kit  >3 publications with GNalphaI3 and RGS19
 GNB2 elisa kit  >1 publications with GNalphaI3 and GNB2
 RGS10 elisa kit  >1 publications with GNalphaI3 and RGS10
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 12 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 12 Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
Diseases associated with GNalphaI3 elisa kitOrgans/Tissues associated with GNalphaI3 elisa kit
 Disease Name  Pubmed Publications
 Death Antibodies  >3 publications with GNalphaI3 and Death
 Disease Models, Animal Antibodies  >3 publications with GNalphaI3 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with GNalphaI3 and Necrosis
 Neurobehavioral Manifestations Antibodies  >1 publications with GNalphaI3 and Neurobehavioral Manifestations
 Memory Disorders Antibodies  >1 publications with GNalphaI3 and Memory Disorders
 Poisoning Antibodies  >1 publications with GNalphaI3 and Poisoning
 Mental Disorders Antibodies  >1 publications with GNalphaI3 and Mental Disorders
 Inflammation Antibodies  >1 publications with GNalphaI3 and Inflammation
 Nervous System Diseases Antibodies  >1 publications with GNalphaI3 and Nervous System Diseases
 Lung Injury Antibodies  >1 publications with GNalphaI3 and Lung Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with GNalphaI3 and Blood
 Brain Antibodies  >7 publications with GNalphaI3 and Brain
 Bone Antibodies  >5 publications with GNalphaI3 and Bone
 Liver Antibodies  >4 publications with GNalphaI3 and Liver
 Eye Antibodies  >4 publications with GNalphaI3 and Eye
 Lung Antibodies  >4 publications with GNalphaI3 and Lung
 Connective Tissue Antibodies  >3 publications with GNalphaI3 and Connective Tissue
 Embryonic Tissue Antibodies  >3 publications with GNalphaI3 and Embryonic Tissue
 Thymus Antibodies  >2 publications with GNalphaI3 and Thymus
 Intestine Antibodies  >2 publications with GNalphaI3 and Intestine
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