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GPR109A elisa kit :: Human G protein-coupled receptor 109A, GPR109A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9300072 GPR109A elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G protein-coupled receptor 109A, GPR109A, ELISA Kit

★Popular Item★
 Also Known As   

Human G protein-coupled receptor 109A, GPR109A ELISA Kit

 Product Gene Name   

GPR109A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 12; NC_000012.11 (123185840..123187904, complement). Location: 12q24.31
 OMIM    609163
 3D Structure    ModBase 3D Structure for Q8TDS4
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GPR109A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GPR109A purchase    MBS9300072 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G protein-coupled receptor 109A, GPR109A, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GPR109A. The ELISA analytical biochemical technique of the MBS9300072 kit is based on GPR109A antibody-GPR109A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GPR109A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GPR109A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GPR109A. It may not necessarily be applicable to this product.
 NCBI GI #    152112976
 NCBI GeneID    338442
 NCBI Accession #    ABS29270.1 [Other Products]
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 UniProt Primary Accession #    Q8TDS4 [Other Products]
 UniProt Secondary Accession #    A0PJL5; A7LGG3 [Other Products]
 UniProt Related Accession #    Q8TDS4 [Other Products]
 Molecular Weight    41,850 Da
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 NCBI Official Full Name    G protein-coupled receptor 109A
 NCBI Official Synonym Full Names    hydroxycarboxylic acid receptor 2
 NCBI Official Symbol    HCAR2 [Similar Products]
 NCBI Official Synonym Symbols   
HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A
[Similar Products]
 NCBI Protein Information    hydroxycarboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor; G protein-coupled receptor 109A; G-protein coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2
 UniProt Protein Name    Hydroxycarboxylic acid receptor 2
 UniProt Synonym Protein Names   
G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor
 UniProt Gene Name    HCAR2 [Similar Products]
 UniProt Synonym Gene Names    GPR109A; HCA2; HM74A; NIACR1 [Similar Products]
 UniProt Entry Name    HCAR2_HUMAN
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 UniProt Comments for GPR109A    GPR109A: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: integral to membrane; plasma membrane

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of lipid catabolic process; neutrophil apoptosis
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 Research Articles on GPR109A    1. A sequence from residues 329 to 343 in the C-terminal tail of HCA plays a crucial role in keeping HCA in an inactive conformation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with GPR109A elisa kitOrgans/Tissues associated with GPR109A elisa kit
 Disease Name  Pubmed Publications
 Flushing Antibodies  >31 publications with GPR109A and Flushing
 Atherosclerosis Antibodies  >16 publications with GPR109A and Atherosclerosis
 Dyslipidemias Antibodies  >10 publications with GPR109A and Dyslipidemias
 Arteriosclerosis Antibodies  >6 publications with GPR109A and Arteriosclerosis
 Inflammation Antibodies  >6 publications with GPR109A and Inflammation
 Neoplasms Antibodies  >5 publications with GPR109A and Neoplasms
 Psoriasis Antibodies  >3 publications with GPR109A and Psoriasis
 Carcinoma, Squamous Cell Antibodies  >3 publications with GPR109A and Carcinoma, Squamous Cell
 Coronary Disease Antibodies  >2 publications with GPR109A and Coronary Disease
 Skin Neoplasms Antibodies  >2 publications with GPR109A and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with GPR109A and Blood
 Skin Antibodies  >16 publications with GPR109A and Skin
 Adipose Tissue Antibodies  >10 publications with GPR109A and Adipose Tissue
 Liver Antibodies  >9 publications with GPR109A and Liver
 Lung Antibodies  >7 publications with GPR109A and Lung
 Intestine Antibodies  >4 publications with GPR109A and Intestine
 Brain Antibodies  >3 publications with GPR109A and Brain
 Eye Antibodies  >2 publications with GPR109A and Eye
 Spleen Antibodies  >2 publications with GPR109A and Spleen
 Muscle Antibodies  >1 publications with GPR109A and Muscle
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