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GDF15 elisa kit :: Human GDF15 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS824466
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96 Tests  /  $470 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF15, ELISA Kit

★Popular Item★
 Also Known As   

Human GDF15 ELISA Kit

 Product Synonym Names    MIC1; PDF; PLAB; PTGFB; Growth/differentiation factor 15; GDF-15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
 Product Gene Name   

GDF15 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605312
 3D Structure    ModBase 3D Structure for Q99988
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 Species Reactivity    Human
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 Specificity    The Human GDF15 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human GDF15 proteins within the range of 7.8 pg/ml - 500 pg/ml.
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 Samples    Cell Culture Supernatants, Serum, Plasma.
 Sensitivity    4 pg/ml.
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 Preparation and Storage    Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GDF15 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GDF15 purchase    MBS824466 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GDF15, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GDF15, with an estimated sensitivity of 4 pg/ml. The ELISA analytical biochemical technique of the MBS824466 kit is based on GDF15 antibody-GDF15 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GDF15 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GDF15. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell Culture Supernatants, Serum, Plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for GDF15 elisa kit

   Principle of the Assay: The Human GDF15 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human GDF15 in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human GDF15 coated on a 96-well plate. Standards and samples are pipetted into the wells and GDF15 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human GDF15 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of GDF15 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background: GDF-15 (Growth differentiation factor 15),also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB, is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. Using FISH, the MIC1 gene is mapped to 19p13.2-p13.1. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF15 showed increased expression and secretion during erythroblast maturation. GDF15 functions as an antiinflammatory cytokine by directly interfering with chemokine signaling and integrin activation.
 Applications Tested/Suitable for GDF15 elisa kit   

Sandwich ELISA (SE)

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 Typical Testing Data/Standard Curve (for reference only) of GDF15 elisa kit    GDF15 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS824466. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product.
 NCBI GI #    153792495
 NCBI GeneID    9518
 NCBI Accession #    NP_004855.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004864.2 [Other Products]
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 UniProt Primary Accession #    Q99988 [Other Products]
 UniProt Secondary Accession #    O14629; P78360; Q9BWA0; Q9NRT0 [Other Products]
 UniProt Related Accession #    Q99988 [Other Products]
 Molecular Weight    34,140 Da
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 NCBI Official Full Name    growth/differentiation factor 15
 NCBI Official Synonym Full Names    growth differentiation factor 15
 NCBI Official Symbol    GDF15 [Similar Products]
 NCBI Official Synonym Symbols   
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
 UniProt Protein Name    Growth/differentiation factor 15
 UniProt Synonym Protein Names   
Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF15 [Similar Products]
 UniProt Synonym Gene Names    MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1 [Similar Products]
 UniProt Entry Name    GDF15_HUMAN
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 NCBI Summary for GDF15    Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
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 UniProt Comments for GDF15    GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; cell-cell signaling; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; signal transduction; cell development
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 Research Articles on GDF15    1. GDF15 may be a promising novel biomarker for the preoperative identification of malignant pelvic disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDF15 elisa kitPathways associated with GDF15 elisa kit
 Reference Product  PubMed Publications
 HAMP elisa kit  >44 publications with GDF15 and HAMP
 TNF elisa kit  >21 publications with GDF15 and TNF
 ATF3 elisa kit  >19 publications with GDF15 and ATF3
 TP53 elisa kit  >10 publications with GDF15 and TP53
 PDF elisa kit  >9 publications with GDF15 and PDF
 HIF1A elisa kit  >8 publications with GDF15 and HIF1A
 FOS elisa kit  >8 publications with GDF15 and FOS
 AKT1 elisa kit  >6 publications with GDF15 and AKT1
 CA2 elisa kit  >1 publications with GDF15 and CA2
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with GDF15 elisa kitOrgans/Tissues associated with GDF15 elisa kit
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >118 publications with GDF15 and Heart Diseases
 Inflammation Antibodies  >81 publications with GDF15 and Inflammation
 Heart Failure Antibodies  >61 publications with GDF15 and Heart Failure
 Gastrointestinal Neoplasms Antibodies  >61 publications with GDF15 and Gastrointestinal Neoplasms
 Anemia Antibodies  >56 publications with GDF15 and Anemia
 Myocardial Ischemia Antibodies  >54 publications with GDF15 and Myocardial Ischemia
 Prostatic Neoplasms Antibodies  >50 publications with GDF15 and Prostatic Neoplasms
 Necrosis Antibodies  >41 publications with GDF15 and Necrosis
 Adenocarcinoma Antibodies  >32 publications with GDF15 and Adenocarcinoma
 Brain Diseases Antibodies  >30 publications with GDF15 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >268 publications with GDF15 and Blood
 Heart Antibodies  >118 publications with GDF15 and Heart
 Bone Antibodies  >80 publications with GDF15 and Bone
 Prostate Antibodies  >71 publications with GDF15 and Prostate
 Brain Antibodies  >71 publications with GDF15 and Brain
 Vascular Antibodies  >49 publications with GDF15 and Vascular
 Liver Antibodies  >44 publications with GDF15 and Liver
 Lung Antibodies  >39 publications with GDF15 and Lung
 Kidney Antibodies  >31 publications with GDF15 and Kidney
 Muscle Antibodies  >29 publications with GDF15 and Muscle
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