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GFRA1 elisa kit :: Human GDNF family receptor alpha-1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2885146 GFRA1 elisa kit
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDNF family receptor alpha-1 (GFRA1), ELISA Kit

 Also Known As   

Human GDNF family receptor alpha-1 ELISA Kit

 Product Synonym Names    GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA; RETL1; TRNR1
 Product Gene Name   

GFRA1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS2885146 Testing Data    Testing Data PDF
 OMIM    601496
 3D Structure    ModBase 3D Structure for P56159
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 Species Reactivity    Human
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 Samples    Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of GFRA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GFRA1 purchase    MBS2885146 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GDNF family receptor alpha-1 (GFRA1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GFRA1. The ELISA analytical biochemical technique of the MBS2885146 kit is based on GFRA1 antibody-GFRA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GFRA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GFRA1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for GFRA1 elisa kit

   Intended Uses||This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
Sample Manual Insert of MBS2885146
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NCBI/Uniprot data below describe general gene information for GFRA1. It may not necessarily be applicable to this product.
 NCBI GI #    224282178
 NCBI GeneID    2674
 NCBI Accession #    NP_001138925.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145453.2 [Other Products]
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 UniProt Primary Accession #    P56159 [Other Products]
 UniProt Secondary Accession #    O15507; O43912; A8KA21 [Other Products]
 UniProt Related Accession #    P56159 [Other Products]
 Molecular Weight    50,838 Da
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 NCBI Official Full Name    GDNF family receptor alpha-1 isoform b
 NCBI Official Synonym Full Names    GDNF family receptor alpha 1
 NCBI Official Symbol    GFRA1 [Similar Products]
 NCBI Official Synonym Symbols   
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
[Similar Products]
 NCBI Protein Information    GDNF family receptor alpha-1
 UniProt Protein Name    GDNF family receptor alpha-1
 UniProt Synonym Protein Names   
RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
 Protein Family    GDNF family receptor
 UniProt Gene Name    GFRA1 [Similar Products]
 UniProt Synonym Gene Names    GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1 [Similar Products]
 UniProt Entry Name    GFRA1_HUMAN
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 NCBI Summary for GFRA1    This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
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 UniProt Comments for GFRA1    GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 10q26.11

Cellular Component: extrinsic to membrane; plasma membrane

Molecular Function: glial cell line-derived neurotrophic factor receptor activity; receptor binding

Biological Process: axon guidance; cell surface receptor linked signal transduction
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 Research Articles on GFRA1    1. This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GFRA1 elisa kitPathways associated with GFRA1 elisa kit
 Reference Product  PubMed Publications
 GDNF elisa kit  >325 publications with GFRA1 and GDNF
 RET elisa kit  >247 publications with GFRA1 and RET
 NRTN elisa kit  >37 publications with GFRA1 and NRTN
 NCAM1 elisa kit  >18 publications with GFRA1 and NCAM1
 SRC elisa kit  >11 publications with GFRA1 and SRC
 ARTN elisa kit  >9 publications with GFRA1 and ARTN
 PSPN elisa kit  >5 publications with GFRA1 and PSPN
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
Diseases associated with GFRA1 elisa kitOrgans/Tissues associated with GFRA1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >57 publications with GFRA1 and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with GFRA1 and Brain Diseases
 Disease Models, Animal Antibodies  >18 publications with GFRA1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >16 publications with GFRA1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >16 publications with GFRA1 and Cardiovascular Diseases
 Infertility, Male Antibodies  >9 publications with GFRA1 and Infertility, Male
 Kidney Diseases Antibodies  >7 publications with GFRA1 and Kidney Diseases
 Necrosis Antibodies  >6 publications with GFRA1 and Necrosis
 Nerve Degeneration Antibodies  >5 publications with GFRA1 and Nerve Degeneration
 Breast Neoplasms Antibodies  >4 publications with GFRA1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >100 publications with GFRA1 and Brain
 Testis Antibodies  >62 publications with GFRA1 and Testis
 Ganglia Antibodies  >49 publications with GFRA1 and Ganglia
 Embryonic Tissue Antibodies  >33 publications with GFRA1 and Embryonic Tissue
 Kidney Antibodies  >30 publications with GFRA1 and Kidney
 Blood Antibodies  >17 publications with GFRA1 and Blood
 Muscle Antibodies  >17 publications with GFRA1 and Muscle
 Intestine Antibodies  >14 publications with GFRA1 and Intestine
 Eye Antibodies  >11 publications with GFRA1 and Eye
 Bone Antibodies  >7 publications with GFRA1 and Bone
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