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GDNF elisa kit :: Human GDNF ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2512291
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

Human GDNF (Glial Cell Line Derived Neurotrophic Factor) ELISA Kit

 Product Gene Name   

GDNF elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    209880
 3D Structure    ModBase 3D Structure for P39905
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human GDNF. No significant cross-reactivity or interference between Human GDNF and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human GDNF and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.313-20ng/mL
 Sensitivity    Min: 0.188ng/mL; Max: 20ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GDNF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GDNF purchase    MBS2512291 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GDNF, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313-20ng/mL in biological research samples containing GDNF, with an estimated sensitivity of Min: 0.188ng/mL; Max: 20ng/mL. The ELISA analytical biochemical technique of the MBS2512291 kit is based on GDNF antibody-GDNF antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GDNF antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GDNF. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GDNF elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of GDNF in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human GDNF. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human GDNF and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human GDNF, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human GDNF. You can calculate the concentration of Human GDNF in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of GDNF elisa kit    GDNF elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2512291. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GDNF. It may not necessarily be applicable to this product.
 NCBI GI #    299473781
 NCBI GeneID    2668
 NCBI Accession #    NP_001177398.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190469.1 [Other Products]
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 UniProt Primary Accession #    P39905 [Other Products]
 UniProt Secondary Accession #    O95448; O95449; O95986; Q6FH33; Q96L44; Q9UD32; Q9UD33; Q9UMV2; Q9UP67; Q9UP97; B7WPK7 [Other Products]
 UniProt Related Accession #    P39905; AAB33493; AAB33494 [Other Products]
 Molecular Weight    18,123 Da
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 NCBI Official Full Name    glial cell line-derived neurotrophic factor isoform 4 preproprotein
 NCBI Official Synonym Full Names    glial cell derived neurotrophic factor
 NCBI Official Symbol    GDNF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor
 UniProt Protein Name    Glial cell line-derived neurotrophic factor
 UniProt Synonym Protein Names   
Astrocyte-derived trophic factor; ATF
 Protein Family    GDNF family receptor
 UniProt Gene Name    GDNF [Similar Products]
 UniProt Synonym Gene Names    hGDNF; ATF [Similar Products]
 UniProt Entry Name    GDNF_HUMAN
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 NCBI Summary for GDNF    This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
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 UniProt Comments for GDNF    GDNF: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13.1-p12

Cellular Component: extracellular region

Molecular Function: protein homodimerization activity; growth factor activity; receptor binding

Biological Process: axon guidance; nervous system development; positive regulation of dopamine secretion; peristalsis; adult locomotory behavior; mRNA stabilization; regulation of dopamine uptake; positive regulation of monooxygenase activity; signal transduction; enteric nervous system development; sympathetic nervous system development; ureteric bud branching; regulation of gene expression; induction of an organ; positive regulation of cell proliferation; postganglionic parasympathetic nervous system development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; postsynaptic membrane organization; positive regulation of cell differentiation; metanephros development; neural crest cell migration; neurite development; negative regulation of apoptosis

Disease: Hirschsprung Disease, Susceptibility To, 3; Central Hypoventilation Syndrome, Congenital; Pheochromocytoma
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 Research Articles on GDNF    1. serum levels of GDNF may be an unsuitable biomarker for schizophrenia, although it may be associated with working memory in healthy controls and the pathophysiology of attention deficits in schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GDNF elisa kitDiseases associated with GDNF elisa kit
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1397 publications with GDNF and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >621 publications with GDNF and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >571 publications with GDNF and Disease Models, Animal
 Movement Disorders Antibodies  >559 publications with GDNF and Movement Disorders
 Parkinsonian Disorders Antibodies  >523 publications with GDNF and Parkinsonian Disorders
 Parkinson Disease Antibodies  >458 publications with GDNF and Parkinson Disease
 Nerve Degeneration Antibodies  >280 publications with GDNF and Nerve Degeneration
 Neurologic Manifestations Antibodies  >195 publications with GDNF and Neurologic Manifestations
 Inflammation Antibodies  >168 publications with GDNF and Inflammation
 Brain Injuries Antibodies  >154 publications with GDNF and Brain Injuries
Organs/Tissues associated with GDNF elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2014 publications with GDNF and Brain
 Embryonic Tissue Antibodies  >377 publications with GDNF and Embryonic Tissue
 Muscle Antibodies  >279 publications with GDNF and Muscle
 Bone Antibodies  >211 publications with GDNF and Bone
 Skin Antibodies  >72 publications with GDNF and Skin
 Ovary Antibodies  >20 publications with GDNF and Ovary
 Placenta Antibodies  >5 publications with GDNF and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with GDNF and Uncharacterized Tissue
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