AAD04926.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,382 Da
NCBI Official Full Name
Grb2-related adaptor protein 2
NCBI Official Synonym Full Names
GRB2-related adaptor protein 2
NCBI Official Synonym Symbols
P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2 [Similar Products]
NCBI Protein Information
GRB2-related adapter protein 2
UniProt Protein Name
GRB2-related adapter protein 2
UniProt Synonym Protein Names
Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona
UniProt Synonym Gene Names
UniProt Entry Name
GRAP2_HUMAN
NCBI Summary for GRAP2
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
UniProt Comments for GRAP2
GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: positive regulation of signal transduction; cell-cell signaling; Ras protein signal transduction; T cell costimulation; innate immune response; T cell receptor signaling pathway
Research Articles on GRAP2
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Pathways associated with GRAP2 elisa kit
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Organs/Tissues associated with GRAP2 elisa kit
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