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GGT1 elisa kit :: Human Gamma-glutamyltranspeptidase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS762013
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $280 +1 FREE 8GB USB
96-Strip-Wells  /  $375 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,015 +3 FREE 8GB USB
15x96-Strip-Wells  /  $4,285 +5 FREE 8GB USB
25x96-Strip-Wells  /  $6,715 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gamma-glutamyltranspeptidase 1 (GGT1), ELISA Kit

★Popular Item★
 Also Known As   

Human Gamma-glutamyltranspeptidase 1 ELISA Kit

 Product Synonym Names    gammaGT1/GGT1 ( (Gamma Glutamyltransferase 1))/GGT/Leukotriene-C4 hydrolase/Glutathione hydrolase 1/Gamma-glutamyltranspeptidase 1
 Product Gene Name   

GGT1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS762013 COA    COA PDF
 OMIM    231950
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of GGT1. No significant cross-reactivity or interference between GGT1 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates and other biological fluids
 Detection Range    1.563-100ng/ml
 Sensitivity    <0.938ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level GGT1 were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level GGT1 were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GGT1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GGT1 purchase    MBS762013 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gamma-glutamyltranspeptidase 1 (GGT1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/ml in biological research samples containing GGT1, with an estimated sensitivity of <0.938ng/ml. The ELISA analytical biochemical technique of the MBS762013 kit is based on GGT1 antibody-GGT1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GGT1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GGT1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GGT1 elisa kit

   Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti- GGT1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti- GGT1 antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the GGT1 amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of GGT1 can be calculated.
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 Typical Testing Data/Standard Curve (for reference only) of GGT1 elisa kit    GGT1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS762013. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GGT1. It may not necessarily be applicable to this product.
 NCBI GI #    572153074
 NCBI GeneID    2678
 NCBI Accession #    NP_038265.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013421.2 [Other Products]
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 UniProt Secondary Accession #    Q08247; Q14404; Q8TBS1; Q9UMK1 [Other Products]
 UniProt Related Accession #    P19440 [Other Products]
 Molecular Weight    24,080 Da
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 NCBI Official Full Name    gamma-glutamyltranspeptidase 1
 NCBI Official Synonym Full Names    gamma-glutamyltransferase 1
 NCBI Official Symbol    GGT1 [Similar Products]
 NCBI Official Synonym Symbols   
GGT; GTG; CD224; GGT 1; D22S672; D22S732
[Similar Products]
 NCBI Protein Information    gamma-glutamyltranspeptidase 1
 UniProt Protein Name    Gamma-glutamyltranspeptidase 1
 UniProt Synonym Protein Names   
Gamma-glutamyltransferase 1; Glutathione hydrolase 1 (EC:3.4.19.13
 Protein Family    Gamma-glutamyltranspeptidase
 UniProt Gene Name    GGT1 [Similar Products]
 UniProt Synonym Gene Names    GGT; GGT 1 [Similar Products]
 UniProt Entry Name    GGT1_HUMAN
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 NCBI Summary for GGT1    The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
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 UniProt Comments for GGT1    GGT1: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. Defects in GGT1 are a cause of glutathionuria (GLUTH); also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease. Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - selenoamino acid; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; EC 3.4.19.14; Other Amino Acids Metabolism - glutathione; EC 3.4.19.13; EC 2.3.2.2; Transferase

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: anchored to external side of plasma membrane; extracellular space; integral to membrane; plasma membrane

Molecular Function: gamma-glutamyltransferase activity; protein binding

Biological Process: amino acid metabolic process; arachidonic acid metabolic process; cysteine biosynthetic process; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione metabolic process; leukotriene biosynthetic process; leukotriene metabolic process; regulation of immune system process; regulation of inflammatory response; spermatogenesis; xenobiotic metabolic process; zymogen activation

Disease: Glutathionuria
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 Research Articles on GGT1    1. Interactive effects of GGT1 G allele and low HDL-cholesterol level on diabetic angiopathy is identified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GGT1 elisa kitPathways associated with GGT1 elisa kit
 Reference Product  PubMed Publications
 GSR elisa kit  >2 publications with GGT1 and GSR
 GPX1 elisa kit  >1 publications with GGT1 and GPX1
 GSTP1 elisa kit  >1 publications with GGT1 and GSTP1
 GCLC elisa kit  >1 publications with GGT1 and GCLC
 Products by Pathway  Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
Diseases associated with GGT1 elisa kitOrgans/Tissues associated with GGT1 elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with GGT1 and Liver Diseases
 Carcinoma Antibodies  >6 publications with GGT1 and Carcinoma
 Breast Neoplasms Antibodies  >4 publications with GGT1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >3 publications with GGT1 and Liver Neoplasms
 Heart Diseases Antibodies  >2 publications with GGT1 and Heart Diseases
 Neoplasms, Experimental Antibodies  >1 publications with GGT1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with GGT1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with GGT1 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >1 publications with GGT1 and Fibrosis
 Liver Neoplasms, Experimental Antibodies  >1 publications with GGT1 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with GGT1 and Blood
 Lung Antibodies  >7 publications with GGT1 and Lung
 Kidney Antibodies  >5 publications with GGT1 and Kidney
 Skin Antibodies  >3 publications with GGT1 and Skin
 Connective Tissue Antibodies  >1 publications with GGT1 and Connective Tissue
 Eye Antibodies  >1 publications with GGT1 and Eye
 Testis Antibodies  >1 publications with GGT1 and Testis
 Uncharacterized Tissue Antibodies  >1 publications with GGT1 and Uncharacterized Tissue
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