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Gas6 elisa kit :: Human Gas6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2509898 Gas6 elisa kit
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gas6, ELISA Kit

 Also Known As   

Human Gas6 (Growth Arrest Specific Protein 6) ELISA Kit

 Product Gene Name   

Gas6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS2509898 COA    COA PDF
 OMIM    600441
 3D Structure    ModBase 3D Structure for Q14393
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant Human Gas6. No significant cross-reactivity or interference between Human Gas6 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Sandwich
 Detection Range    62.5-4000pg/mL
 Sensitivity    The minimum detectable dose of Human Gas6 is 37.5pg/mL
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of Gas6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Gas6 purchase    MBS2509898 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gas6, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5-4000pg/mL in biological research samples containing Gas6, with an estimated sensitivity of The minimum detectable dose of Human Gas6 is 37.5pg/mL. The ELISA analytical biochemical technique of the MBS2509898 kit is based on Gas6 antibody-Gas6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Gas6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Gas6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for Gas6 elisa kit

   Intended Uses||This ELISA kit applies to the in vitro quantitative determination of Human Gas6 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Gas6. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Gas6 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Gas6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Gas6. You can calculate the concentration of Gas6 in the samples by comparing the OD of the samples to the standard curve.
Sample Manual Insert of MBS2509898
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NCBI/Uniprot data below describe general gene information for Gas6. It may not necessarily be applicable to this product.
 NCBI GI #    221316738
 NCBI GeneID    2621
 NCBI Accession #    NP_001137418.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143946.1 [Other Products]
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 UniProt Primary Accession #    Q14393 [Other Products]
 UniProt Secondary Accession #    Q6IMN1; Q7Z7N3; B3KRQ7; B3KVL4; E9PBL7 [Other Products]
 UniProt Related Accession #    Q14393 [Other Products]
 Molecular Weight    41,986 Da
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 NCBI Official Synonym Full Names    growth arrest-specific 6
 NCBI Official Symbol    GAS6 [Similar Products]
 NCBI Official Synonym Symbols   
AXSF; AXLLG
[Similar Products]
 NCBI Protein Information    growth arrest-specific protein 6
 UniProt Protein Name    Growth arrest-specific protein 6
 UniProt Synonym Protein Names   
AXL receptor tyrosine kinase ligand
 Protein Family    Growth arrest-specific protein
 UniProt Gene Name    GAS6 [Similar Products]
 UniProt Synonym Gene Names    AXLLG; GAS-6 [Similar Products]
 UniProt Entry Name    GAS6_HUMAN
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 NCBI Summary for Gas6    This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
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 UniProt Comments for Gas6    GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Ligand, receptor tyrosine kinase; Secreted

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; cytoplasm; extracellular region

Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding

Biological Process: entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; proteolysis; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; platelet degranulation; negative regulation of protein import into nucleus, translocation; positive regulation of glomerular filtration; regulation of growth; positive regulation of phagocytosis; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of interleukin-6 production; cell adhesion; cell cycle arrest; positive regulation of TOR signaling pathway; platelet activation; virion attachment, binding of host cell surface receptor; cell migration; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; negative regulation of tumor necrosis factor production; viral genome replication; cellular response to starvation; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; negative regulation of transcription, DNA-dependent; negative regulation of interleukin-1 secretion; leukocyte migration; apoptotic cell clearance; negative regulation of apoptosis
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 Research Articles on Gas6    1. These results suggest that plasma Gas6 is associated with sex hormones in both pre- and postmenopausal women
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Gas6 elisa kitPathways associated with Gas6 elisa kit
 Reference Product  PubMed Publications
 AXL elisa kit  >269 publications with Gas6 and AXL
 TYRO3 elisa kit  >106 publications with Gas6 and TYRO3
 MERTK elisa kit  >77 publications with Gas6 and MERTK
 EGF elisa kit  >10 publications with Gas6 and EGF
 TGFB1 elisa kit  >3 publications with Gas6 and TGFB1
 SERPINE1 elisa kit  >2 publications with Gas6 and SERPINE1
 GGCX elisa kit  >1 publications with Gas6 and GGCX
 FN1 elisa kit  >1 publications with Gas6 and FN1
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway antibodies  Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway Diagram
Diseases associated with Gas6 elisa kitOrgans/Tissues associated with Gas6 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >62 publications with Gas6 and Inflammation
 Cardiovascular Diseases Antibodies  >53 publications with Gas6 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >32 publications with Gas6 and Disease Models, Animal
 Necrosis Antibodies  >31 publications with Gas6 and Necrosis
 Thrombosis Antibodies  >29 publications with Gas6 and Thrombosis
 Kidney Diseases Antibodies  >27 publications with Gas6 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >14 publications with Gas6 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >12 publications with Gas6 and Lung Neoplasms
 Adenocarcinoma Antibodies  >11 publications with Gas6 and Adenocarcinoma
 Breast Neoplasms Antibodies  >10 publications with Gas6 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >112 publications with Gas6 and Blood
 Vascular Antibodies  >83 publications with Gas6 and Vascular
 Bone Antibodies  >45 publications with Gas6 and Bone
 Muscle Antibodies  >45 publications with Gas6 and Muscle
 Kidney Antibodies  >35 publications with Gas6 and Kidney
 Brain Antibodies  >28 publications with Gas6 and Brain
 Bone Marrow Antibodies  >27 publications with Gas6 and Bone Marrow
 Liver Antibodies  >22 publications with Gas6 and Liver
 Lung Antibodies  >18 publications with Gas6 and Lung
 Eye Antibodies  >16 publications with Gas6 and Eye
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