CAG33079.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
58,226 Da
NCBI Official Full Name
GTF2F1
NCBI Official Synonym Full Names
general transcription factor IIF, polypeptide 1, 74kDa
NCBI Protein Information
general transcription factor IIF subunit 1; TFIIF-alpha; transcription initiation factor RAP74; general transcription factor IIF 74 kDa subunit; transcription initiation factor IIF subunit alpha
UniProt Protein Name
GTF2F1 protein
UniProt Entry Name
Q6IBK5_HUMAN
UniProt Comments for GTF2F1
GTF2F1: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the TFIIF alpha subunit family.
Protein type: EC 2.7.11.1; Kinase, protein; Transcription initiation complex; ATYPICAL group; GTF2F1 family
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; transcription factor TFIIF complex; nucleus; cell junction
Molecular Function: protein binding; DNA binding; phosphatase activator activity; transcription coactivator activity; catalytic activity; transcription factor binding
Biological Process: positive regulation of catalytic activity; nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; mRNA capping; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; RNA splicing; response to virus; RNA elongation from RNA polymerase II promoter; gene expression
Research Articles on GTF2F1
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Pathways associated with GTF2F1 elisa kit
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