P01275.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Glucagon
NCBI Official Synonym Full Names
glucagon
NCBI Protein Information
glucagon
UniProt Protein Name
Glucagon
UniProt Synonym Protein Names
GlicentinGlicentin-related polypeptide; GRPP
UniProt Synonym Gene Names
NCBI Summary for GCG
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
UniProt Comments for GCG
GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; receptor binding
Biological Process: cell proliferation; feeding behavior; G-protein coupled receptor protein signaling pathway; regulation of insulin secretion; signal transduction
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Products associated with GCG elisa kit
Pathways associated with GCG elisa kit
Diseases associated with GCG elisa kit
Organs/Tissues associated with GCG elisa kit
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