NP_003792.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,098 Da
NCBI Official Full Name
glycosylphosphatidylinositol anchor attachment 1 protein
NCBI Official Synonym Full Names
glycosylphosphatidylinositol anchor attachment 1
NCBI Protein Information
glycosylphosphatidylinositol anchor attachment 1 protein
UniProt Protein Name
Glycosylphosphatidylinositol anchor attachment 1 protein
UniProt Synonym Protein Names
GAA1 protein homolog; hGAA1
UniProt Synonym Gene Names
NCBI Summary for GPAA1
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
UniProt Comments for GPAA1
GPAA1: Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: endoplasmic reticulum membrane; GPI-anchor transamidase complex; membrane
Molecular Function: GPI-anchor transamidase activity; protein binding; tubulin binding
Biological Process: attachment of GPI anchor to protein; protein complex assembly; protein retention in ER
Disease: Glycosylphosphatidylinositol Biosynthesis Defect 15
Research Articles on GPAA1
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Products associated with GPAA1 elisa kit
Pathways associated with GPAA1 elisa kit
Diseases associated with GPAA1 elisa kit
Organs/Tissues associated with GPAA1 elisa kit
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