NP_001001555.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,487 Da
NCBI Official Full Name
growth factor receptor-bound protein 10 isoform c
NCBI Official Synonym Full Names
growth factor receptor-bound protein 10
NCBI Official Synonym Symbols
RSS; IRBP; MEG1; GRB-IR; Grb-10 [Similar Products]
NCBI Protein Information
growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; insulin receptor-binding protein Grb-IR; maternally expressed gene 1
UniProt Protein Name
Growth factor receptor-bound protein 10
UniProt Synonym Protein Names
GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
UniProt Synonym Gene Names
UniProt Entry Name
GRB10_HUMAN
NCBI Summary for Grb10
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
UniProt Comments for Grb10
GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding
Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin stimulus; negative regulation of glycogen biosynthetic process
Research Articles on Grb10
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Pathways associated with Grb10 elisa kit
Diseases associated with Grb10 elisa kit
Organs/Tissues associated with Grb10 elisa kit
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