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GDF6 elisa kit :: Human Growth Differentiation Factor 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS763810
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $280 +1 FREE 8GB USB
96-Strip-Wells  /  $375 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,015 +3 FREE 8GB USB
15x96-Strip-Wells  /  $4,285 +5 FREE 8GB USB
25x96-Strip-Wells  /  $6,715 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Differentiation Factor 6 (GDF6), ELISA Kit

★Popular Item★
 Also Known As   

Human Growth Differentiation Factor 6 ELISA Kit

 Product Synonym Names    GDF6/BMP-13/BMP13/CDMP2/GDF16/GDF-6/growth differentiation factor 6/Growth/differentiation factor 16/growth/differentiation factor 6/KFS/KFS1/KFSL/MCOP4/MCOPCB6/MGC158100/MGC158101/SCDO4/SGM1
 Product Gene Name   

GDF6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS763810 QC Report    QC Report PDF
 OMIM    118100
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of GDF6. No significant cross-reactivity or interference between GDF6 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Sandwich ELISA, Double Antibody
 Detection Range    0.156-10ng/ml
 Sensitivity    0.094ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level GDF6 were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level GDF6 were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GDF6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GDF6 purchase    MBS763810 is a ready-to-use microwell, strip plate Sandwich, Double Antibody ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Differentiation Factor 6 (GDF6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/ml in biological research samples containing GDF6, with an estimated sensitivity of 0.094ng/ml. The ELISA analytical biochemical technique of the MBS763810 kit is based on GDF6 antibody-GDF6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GDF6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GDF6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GDF6 elisa kit

   Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti- GDF6 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti- GDF6 antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the GDF6 amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of GDF6 can be calculated.
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 Typical Testing Data/Standard Curve (for reference only) of GDF6 elisa kit    GDF6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS763810. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GDF6. It may not necessarily be applicable to this product.
 NCBI GI #    119612153
 NCBI GeneID    392255
 NCBI Accession #    EAW91747.1 [Other Products]
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 UniProt Secondary Accession #    Q6PI58 [Other Products]
 UniProt Related Accession #    Q6KF10 [Other Products]
 Molecular Weight    50,662 Da
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 NCBI Official Full Name    growth differentiation factor 6, partial
 NCBI Official Synonym Full Names    growth differentiation factor 6
 NCBI Official Symbol    GDF6 [Similar Products]
 NCBI Official Synonym Symbols   
KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 6
 UniProt Protein Name    Growth/differentiation factor 6
 UniProt Synonym Protein Names   
Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF6 [Similar Products]
 UniProt Synonym Gene Names    BMP13; GDF16; GDF-6; BMP-13 [Similar Products]
 UniProt Entry Name    GDF6_HUMAN
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 NCBI Summary for GDF6    This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GDF6    GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation; Cytokine

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; apoptosis; BMP signaling pathway; cell development; growth; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Leber Congenital Amaurosis 17; Microphthalmia, Isolated 4; Microphthalmia, Isolated, With Coloboma 6
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 Research Articles on GDF6    1. GDF6 is overexpressed in Leri's pleonosteosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDF6 elisa kitPathways associated with GDF6 elisa kit
 Reference Product  PubMed Publications
 BMPR2 elisa kit  >5 publications with GDF6 and BMPR2
 SMAD5 elisa kit  >1 publications with GDF6 and SMAD5
 BMPR1A elisa kit  >1 publications with GDF6 and BMPR1A
 NOG elisa kit  >1 publications with GDF6 and NOG
 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with GDF6 elisa kitOrgans/Tissues associated with GDF6 elisa kit
 Disease Name  Pubmed Publications
 Growth Disorders Antibodies  >7 publications with GDF6 and Growth Disorders
 Klippel-Feil Syndrome Antibodies  >7 publications with GDF6 and Klippel-Feil Syndrome
 Coloboma Antibodies  >7 publications with GDF6 and Coloboma
 Inflammation Antibodies  >2 publications with GDF6 and Inflammation
 Fibrosis Antibodies  >2 publications with GDF6 and Fibrosis
 Neovascularization, Pathologic Antibodies  >2 publications with GDF6 and Neovascularization, Pathologic
 Metaplasia Antibodies  >2 publications with GDF6 and Metaplasia
 Liver Diseases Antibodies  >1 publications with GDF6 and Liver Diseases
 Learning Disorders Antibodies  >1 publications with GDF6 and Learning Disorders
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with GDF6 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >51 publications with GDF6 and Bone
 Embryonic Tissue Antibodies  >6 publications with GDF6 and Embryonic Tissue
 Brain Antibodies  >3 publications with GDF6 and Brain
 Placenta Antibodies  >1 publications with GDF6 and Placenta
 Testis Antibodies  >1 publications with GDF6 and Testis
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