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HAX1 elisa kit :: Human HCLS1 associated protein X-1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9340208 HAX1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HCLS1 associated protein X-1 (HAX1), ELISA Kit

 Also Known As   

Human HCLS1-associated protein X-1, HAX1 ELISA Kit

 Product Synonym Names    Human HCLS1-associated protein X-1 (HAX1) ELISA kit; RP11-137P24.1; FLJ17042; FLJ18492; FLJ93803; HCLSBP1; HS1BP1; SCN3; HCLS1 (and PKD2) associated protein; HS1 binding protein; HCLS1 associated protein X-1
 Product Gene Name   

HAX1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 610738
 3D Structure    ModBase 3D Structure for O00165
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HAX1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HAX1 purchase    MBS9340208 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the HCLS1 associated protein X-1 (HAX1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HAX1. The ELISA analytical biochemical technique of the MBS9340208 kit is based on HAX1 antibody-HAX1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HAX1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HAX1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HAX1. It may not necessarily be applicable to this product.
 NCBI GI #    66363694
 NCBI GeneID    10456
 NCBI Accession #    NP_001018238.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018837.1 [Other Products]
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 UniProt Primary Accession #    O00165 [Other Products]
 UniProt Secondary Accession #    Q5VYD5; Q5VYD7; Q96AU4; Q9BS80; A8W4W9; A8W4X0; B4DUJ7 [Other Products]
 UniProt Related Accession #    O00165 [Other Products]
 Molecular Weight    31,621 Da
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 NCBI Official Full Name    HCLS1-associated protein X-1 isoform b
 NCBI Official Synonym Full Names    HCLS1 associated protein X-1
 NCBI Official Symbol    HAX1 [Similar Products]
 NCBI Official Synonym Symbols   
SCN3; HS1BP1; HCLSBP1
[Similar Products]
 NCBI Protein Information    HCLS1-associated protein X-1; HAX-1; HSP1BP-1; HS1 binding protein; HS1-binding protein 1; HS1-associating protein X-1; HCLS1 (and PKD2) associated protein
 UniProt Protein Name    HCLS1-associated protein X-1
 UniProt Synonym Protein Names   
HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
 Protein Family    HCLS1-associated protein
 UniProt Gene Name    HAX1 [Similar Products]
 UniProt Synonym Gene Names    HS1BP1; HAX-1; HSP1BP-1 [Similar Products]
 UniProt Entry Name    HAX1_HUMAN
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 NCBI Summary for HAX1    The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HAX1    HAX1: Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3); also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms. Belongs to the HAX1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Endoplasmic reticulum; Apoptosis; Vesicle

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: transcription factor complex; nuclear membrane; clathrin-coated vesicle; sarcoplasmic reticulum; mitochondrion; endoplasmic reticulum; lamellipodium; apical plasma membrane; nuclear envelope; actin cytoskeleton

Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding; interleukin-1 binding

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of apoptosis; positive regulation of protein kinase B signaling cascade; regulation of actin filament polymerization; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of granulocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation

Disease: Neutropenia, Severe Congenital, 3, Autosomal Recessive
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 Research Articles on HAX1    1. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HAX1 elisa kitDiseases associated with HAX1 elisa kit
 Reference Product  PubMed Publications
 HCLS1 elisa kit  >4 publications with HAX1 and HCLS1
 CTTN elisa kit  >3 publications with HAX1 and CTTN
 PKD2 elisa kit  >2 publications with HAX1 and PKD2
 ABCB11 elisa kit  >1 publications with HAX1 and ABCB11
 ABCB1 elisa kit  >1 publications with HAX1 and ABCB1
 Disease Name  Pubmed Publications
 Agranulocytosis Antibodies  >53 publications with HAX1 and Agranulocytosis
 Leukopenia Antibodies  >53 publications with HAX1 and Leukopenia
 Nervous System Diseases Antibodies  >7 publications with HAX1 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with HAX1 and Cell Transformation, Neoplastic
 NEUTROPENIA, SEVERE CONGENITAL, 3, AUTOSOMAL RECESSIVE Antibodies  >6 publications with HAX1 and NEUTROPENIA, SEVERE CONGENITAL, 3, AUTOSOMAL RECESSIVE
 Mitochondrial Diseases Antibodies  >5 publications with HAX1 and Mitochondrial Diseases
 Seizures Antibodies  >3 publications with HAX1 and Seizures
 Fever Antibodies  >2 publications with HAX1 and Fever
 Heart Diseases Antibodies  >2 publications with HAX1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with HAX1 and Cardiovascular Diseases
Organs/Tissues associated with HAX1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with HAX1 and Blood
 Bone Antibodies  >15 publications with HAX1 and Bone
 Bone Marrow Antibodies  >15 publications with HAX1 and Bone Marrow
 Muscle Antibodies  >8 publications with HAX1 and Muscle
 Heart Antibodies  >7 publications with HAX1 and Heart
 Skin Antibodies  >6 publications with HAX1 and Skin
 Liver Antibodies  >5 publications with HAX1 and Liver
 Kidney Antibodies  >5 publications with HAX1 and Kidney
 Brain Antibodies  >5 publications with HAX1 and Brain
 Pancreas Antibodies  >3 publications with HAX1 and Pancreas
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