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HBb elisa kit :: Human Hemoglobin Beta (HBb) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2023098 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $270 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $665 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,715 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,895 +6 FREE 8GB USB
 
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 Product Name   

Hemoglobin Beta (HBb), ELISA Kit

★Popular Item★
 Also Known As   

Hemoglobin Beta (HBb) ELISA Kit

 Product Synonym Names    HB-B; HBD; CD113t-C; Beta Globin; Spinorphin
 Product Gene Name   

HBb elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Hemoglobin Beta (HBb).
No significant cross-reactivity or interference between Hemoglobin Beta (HBb) and analogues was observed.
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 Assay Type    Competitive Inhibition
 Samples    Serum, Plasma and Erythrocyte lysates
 Detection Range    6.17-500ug/mL
 Sensitivity    < 2.94ug/mL
 Application    Enzyme-linked immunosorbent assay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level Hemoglobin Beta (HBb) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level Hemoglobin Beta (HBb) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HBb elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HBb purchase    MBS2023098 is a ready-to-use microwell, strip plate Competitive Inhibition ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hemoglobin Beta (HBb) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.17-500ug/mL in biological research samples containing HBb, with an estimated sensitivity of < 2.94ug/mL. The ELISA analytical biochemical technique of the MBS2023098 kit is based on HBb antibody-HBb antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HBb antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HBb. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma and Erythrocyte lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for HBb elisa kit

   This assay employs the competitive inhibition enzyme immunoassay technique. A monoclonal antibody specific to Hemoglobin Beta (HBb) has been pre-coated onto a microplate. A competitive inhibition reaction is launched between biotin labeled Hemoglobin Beta (HBb) and unlabeled Hemoglobin Beta (HBb) (Standards or samples) with the pre-coated antibody specific to Hemoglobin Beta (HBb). After incubation the unbound conjugate is washed off. Next, avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. The amount of bound HRP conjugate is reverse proportional to the concentration of Hemoglobin Beta (HBb) in the sample. After addition of the substrate solution, the intensity of color developed is reverse proportional to the concentration of Hemoglobin Beta (HBb) in the sample.
 Product Categories/Family for HBb elisa kit    Hematology
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 Typical Testing Data/Standard Curve (for reference only) of HBb elisa kit    HBb elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2023098. Click to request current manual
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NCBI/Uniprot data below describe general gene information for HBb. It may not necessarily be applicable to this product.
 NCBI GI #    410178713
 NCBI GeneID    3043
 NCBI Accession #    AFV63187.1 [Other Products]
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 UniProt Related Accession #    P68871 [Other Products]
 Molecular Weight    3,138 Da
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 NCBI Official Full Name    hemoglobin beta, partial
 NCBI Official Synonym Full Names    hemoglobin, beta
 NCBI Official Symbol    HBB [Similar Products]
 NCBI Official Synonym Symbols   
CD113t-C; beta-globin
[Similar Products]
 NCBI Protein Information    hemoglobin subunit beta
 UniProt Protein Name    Beta-globin
 UniProt Synonym Protein Names   
Beta-globin
 Protein Family    Hemoglobin
 UniProt Gene Name    HBB [Similar Products]
 UniProt Entry Name    Q7Z2K5_HUMAN
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 NCBI Summary for HBb    The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HBb    HBB: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBB may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBB are the cause of beta-thalassemia (B-THAL). A form of thalassemia. Thalassemias are common monogenic diseases occurring mostly in Mediterranean and Southeast Asian populations. The hallmark of beta-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. Absence of beta chain causes beta(0)-thalassemia, while reduced amounts of detectable beta globin causes beta(+)-thalassemia. In the severe forms of beta-thalassemia, the excess alpha globin chains accumulate in the developing erythroid precursors in the marrow. Their deposition leads to a vast increase in erythroid apoptosis that in turn causes ineffective erythropoiesis and severe microcytic hypochromic anemia. Clinically, beta-thalassemia is divided into thalassemia major which is transfusion dependent, thalassemia intermedia (of intermediate severity), and thalassemia minor that is asymptomatic. Defects in HBB are the cause of sickle cell anemia (SKCA); also known as sickle cell disease. Sickle cell anemia is characterized by abnormally shaped red cells resulting in chronic anemia and periodic episodes of pain, serious infections and damage to vital organs. Normal red blood cells are round and flexible and flow easily through blood vessels, but in sickle cell anemia, the abnormal hemoglobin (called Hb S) causes red blood cells to become stiff. They are C-shaped and resembles a sickle. These stiffer red blood cells can led to microvascular occlusion thus cutting off the blood supply to nearby tissues. Defects in HBB are the cause of beta-thalassemia dominant inclusion body type (B-THALIB). An autosomal dominant form of beta thalassemia characterized by moderate anemia, lifelong jaundice, cholelithiasis and splenomegaly, marked morphologic changes in the red cells, erythroid hyperplasia of the bone marrow with increased numbers of multinucleate red cell precursors, and the presence of large inclusion bodies in the normoblasts, both in the marrow and in the peripheral blood after splenectomy. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; extracellular region; cytosol

Molecular Function: haptoglobin binding; protein binding; peroxidase activity; hemoglobin binding; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: receptor-mediated endocytosis; positive regulation of nitric oxide biosynthetic process; response to hydrogen peroxide; nitric oxide transport; protein heterooligomerization; bicarbonate transport; oxygen transport; hydrogen peroxide catabolic process; regulation of blood pressure; blood coagulation; regulation of blood vessel size

Disease: Fetal Hemoglobin Quantitative Trait Locus 1; Beta-thalassemia; Sickle Cell Anemia; Heinz Body Anemias; Beta-thalassemia, Dominant Inclusion Body Type; Malaria, Susceptibility To; Alpha-thalassemia
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 Research Articles on HBb    1. The Filipino beta-deletion represented the majority of the beta-thalassemia alleles in the indigenous patients in Malaysia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HBb elisa kitPathways associated with HBb elisa kit
 Reference Product  PubMed Publications
 HBA2 elisa kit  >31 publications with HBb and HBA2
 HBA1 elisa kit  >21 publications with HBb and HBA1
 HBG2 elisa kit  >16 publications with HBb and HBG2
 KLF1 elisa kit  >9 publications with HBb and KLF1
 HPX elisa kit  >4 publications with HBb and HPX
 HBZ elisa kit  >3 publications with HBb and HBZ
 AQP1 elisa kit  >1 publications with HBb and AQP1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with HBb elisa kitOrgans/Tissues associated with HBb elisa kit
 Disease Name  Pubmed Publications
 Anemia Antibodies  >228 publications with HBb and Anemia
 beta-Thalassemia Antibodies  >205 publications with HBb and beta-Thalassemia
 Hemoglobinopathies Antibodies  >204 publications with HBb and Hemoglobinopathies
 Anemia, Sickle Cell Antibodies  >67 publications with HBb and Anemia, Sickle Cell
 alpha-Thalassemia Antibodies  >65 publications with HBb and alpha-Thalassemia
 Disease Models, Animal Antibodies  >36 publications with HBb and Disease Models, Animal
 Chromosome Aberrations Antibodies  >18 publications with HBb and Chromosome Aberrations
 Liver Diseases Antibodies  >14 publications with HBb and Liver Diseases
 Liver Neoplasms Antibodies  >11 publications with HBb and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with HBb and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >264 publications with HBb and Blood
 Liver Antibodies  >71 publications with HBb and Liver
 Brain Antibodies  >30 publications with HBb and Brain
 Bone Antibodies  >30 publications with HBb and Bone
 Kidney Antibodies  >23 publications with HBb and Kidney
 Bone Marrow Antibodies  >21 publications with HBb and Bone Marrow
 Muscle Antibodies  >20 publications with HBb and Muscle
 Eye Antibodies  >19 publications with HBb and Eye
 Heart Antibodies  >18 publications with HBb and Heart
 Lung Antibodies  >14 publications with HBb and Lung
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