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HMGA2 elisa kit :: Human High mobility group protein HMGI-C (HMGA2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9329886 HMGA2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

High mobility group protein HMGI-C (HMGA2), ELISA Kit

★Popular Item★
 Also Known As   

Human High mobility group protein HMGI-C (HMGA2) ELISA Kit

 Product Synonym Names    high mobility group AT-hook 2; BABL; HMGI-C; HMGIC; LIPO; STQTL9; High-mobility group protein HMGI-C|high-mobility group (nonhistone chromosomal) protein isoform I-C
 Product Gene Name   

HMGA2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 12; NC_000012.11 (66218240..66360071). Location: 12q15
 OMIM    150699
 3D Structure    ModBase 3D Structure for P52926
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HMGA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HMGA2 purchase    MBS9329886 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the High mobility group protein HMGI-C (HMGA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HMGA2. The ELISA analytical biochemical technique of the MBS9329886 kit is based on HMGA2 antibody-HMGA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HMGA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HMGA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS9329886. Click to request current manual
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NCBI/Uniprot data below describe general gene information for HMGA2. It may not necessarily be applicable to this product.
 NCBI GI #    4504431
 NCBI GeneID    8091
 NCBI Accession #    NP_003474.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003483.4 [Other Products]
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 UniProt Primary Accession #    P52926 [Other Products]
 UniProt Secondary Accession #    Q1M182 [Other Products]
 UniProt Related Accession #    P52926 [Other Products]
 Molecular Weight    11,832 Da
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 NCBI Official Full Name    high mobility group protein HMGI-C isoform a
 NCBI Official Synonym Full Names    high mobility group AT-hook 2
 NCBI Official Symbol    HMGA2 [Similar Products]
 NCBI Official Synonym Symbols   
BABL; LIPO; HMGIC; HMGI-C; STQTL9
[Similar Products]
 NCBI Protein Information    high mobility group protein HMGI-C; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group (nonhistone chromosomal) protein isoform I-C
 UniProt Protein Name    High mobility group protein HMGI-C
 UniProt Synonym Protein Names   
High mobility group AT-hook protein 2
 Protein Family    High mobility group protein
 UniProt Gene Name    HMGA2 [Similar Products]
 UniProt Synonym Gene Names    HMGIC [Similar Products]
 UniProt Entry Name    HMGA2_HUMAN
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 NCBI Summary for HMGA2    This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HMGA2    HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; nuclear chromosome; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; transcription factor binding; DNA bending activity

Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription, DNA-dependent; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; chondrocyte differentiation; mitosis; negative regulation of retroviral genome replication; transcription, DNA-dependent; response to virus; heterochromatin formation; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Leiomyoma, Uterine
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 Research Articles on HMGA2    1. Found increased HMGA2 expression in HCC was significantly associated with poor prognosis and low overall survival. Multivariate analysis showed that HMGA2 protein expression was an independent prognostic factor associated with overall survival rate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HMGA2 elisa kitPathways associated with HMGA2 elisa kit
 Reference Product  PubMed Publications
 SMAD3 elisa kit  >2 publications with HMGA2 and SMAD3
 PIAS3 elisa kit  >1 publications with HMGA2 and PIAS3
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with HMGA2 elisa kitOrgans/Tissues associated with HMGA2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >355 publications with HMGA2 and Neoplasms
 LIPOMATOSIS, MULTIPLE Antibodies  >85 publications with HMGA2 and LIPOMATOSIS, MULTIPLE
 Carcinoma Antibodies  >79 publications with HMGA2 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >50 publications with HMGA2 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >38 publications with HMGA2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >29 publications with HMGA2 and Lung Neoplasms
 Hematologic Diseases Antibodies  >26 publications with HMGA2 and Hematologic Diseases
 Nervous System Diseases Antibodies  >23 publications with HMGA2 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >21 publications with HMGA2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >20 publications with HMGA2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >43 publications with HMGA2 and Lung
 Embryonic Tissue Antibodies  >42 publications with HMGA2 and Embryonic Tissue
 Thyroid Antibodies  >27 publications with HMGA2 and Thyroid
 Bone Antibodies  >25 publications with HMGA2 and Bone
 Uterus Antibodies  >19 publications with HMGA2 and Uterus
 Mouth Antibodies  >15 publications with HMGA2 and Mouth
 Connective Tissue Antibodies  >15 publications with HMGA2 and Connective Tissue
 Vascular Antibodies  >13 publications with HMGA2 and Vascular
 Heart Antibodies  >12 publications with HMGA2 and Heart
 Liver Antibodies  >11 publications with HMGA2 and Liver
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