NP_001137300.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,497 Da
NCBI Official Full Name
histamine H4 receptor isoform 2
NCBI Official Synonym Full Names
histamine receptor H4
NCBI Official Synonym Symbols
H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105 [Similar Products]
NCBI Protein Information
histamine H4 receptor
UniProt Protein Name
Histamine H4 receptor
UniProt Synonym Protein Names
AXOR35; G-protein coupled receptor 105; GPRv53; Pfi-013; SP9144
UniProt Synonym Gene Names
UniProt Entry Name
HRH4_HUMAN
NCBI Summary for HRH4
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for HRH4
H4R: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: histamine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; regulation of MAPKKK cascade; inflammatory response
Research Articles on HRH4
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Pathways associated with HRH4 elisa kit
Diseases associated with HRH4 elisa kit
Organs/Tissues associated with HRH4 elisa kit
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