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HAS2 elisa kit :: Human Hyaluronan synthase 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2882985
Typical Standard Curve/Testing Data
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hyaluronan synthase 2 (HAS2), ELISA Kit

★Popular Item★
 Also Known As   

Human Hyaluronan synthase 2 ELISA Kit

 Product Synonym Names    Hyaluronan synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2; HAS2
 Product Gene Name   

HAS2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2882985 Testing Data    Testing Data PDF
 OMIM    601636
 3D Structure    ModBase 3D Structure for Q92819
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 Species Reactivity    Human
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 Samples    Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HAS2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HAS2 purchase    MBS2882985 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hyaluronan synthase 2 (HAS2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HAS2. The ELISA analytical biochemical technique of the MBS2882985 kit is based on HAS2 antibody-HAS2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HAS2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HAS2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for HAS2 elisa kit

   Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Standard Curve/Testing Data of HAS2 elisa kit    HAS2 elisa kit Typical Standard Curve/Testing Data image
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Sample Manual Insert of MBS2882985. Click to request current manual
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NCBI/Uniprot data below describe general gene information for HAS2. It may not necessarily be applicable to this product.
 NCBI GI #    4885391
 NCBI GeneID    3037
 NCBI Accession #    NP_005319.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005328.2 [Other Products]
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 UniProt Primary Accession #    Q92819 [Other Products]
 UniProt Secondary Accession #    Q32MM3 [Other Products]
 UniProt Related Accession #    Q92819 [Other Products]
 Molecular Weight    63,566 Da
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 NCBI Official Full Name    hyaluronan synthase 2
 NCBI Official Synonym Full Names    hyaluronan synthase 2
 NCBI Official Symbol    HAS2 [Similar Products]
 NCBI Protein Information    hyaluronan synthase 2
 UniProt Protein Name    Hyaluronan synthase 2
 UniProt Synonym Protein Names   
Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2
 Protein Family    Hyaluronan synthase
 UniProt Gene Name    HAS2 [Similar Products]
 UniProt Synonym Gene Names    HA synthase 2 [Similar Products]
 UniProt Entry Name    HYAS2_HUMAN
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 NCBI Summary for HAS2    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HAS2    HAS2: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Expressed in fibroblasts. Belongs to the nodC/HAS family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Transferase; EC 2.4.1.212

Chromosomal Location of Human Ortholog: 8q24.12

Cellular Component: cytoplasm; integral to plasma membrane

Molecular Function: hyaluronan synthase activity

Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; kidney development; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of keratinocyte migration; positive regulation of smooth muscle cell migration; vasculogenesis
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 Research Articles on HAS2    1. Our study identified HAS2 as a novel candidate gene for susceptibility to adult asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HAS2 elisa kitPathways associated with HAS2 elisa kit
 Reference Product  PubMed Publications
 HYAL2 elisa kit  >36 publications with HAS2 and HYAL2
 GDF9 elisa kit  >19 publications with HAS2 and GDF9
 SP1 elisa kit  >7 publications with HAS2 and SP1
 BMP2 elisa kit  >5 publications with HAS2 and BMP2
 BMP7 elisa kit  >4 publications with HAS2 and BMP7
 TBX2 elisa kit  >3 publications with HAS2 and TBX2
 HNF4G elisa kit  >1 publications with HAS2 and HNF4G
 TIMP1 elisa kit  >1 publications with HAS2 and TIMP1
 GFPT1 elisa kit  >1 publications with HAS2 and GFPT1
 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Biosynthesis And Export Pathway antibodies  Hyaluronan Biosynthesis And Export Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
Diseases associated with HAS2 elisa kitOrgans/Tissues associated with HAS2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >37 publications with HAS2 and Inflammation
 Cardiovascular Diseases Antibodies  >36 publications with HAS2 and Cardiovascular Diseases
 Necrosis Antibodies  >32 publications with HAS2 and Necrosis
 Breast Neoplasms Antibodies  >25 publications with HAS2 and Breast Neoplasms
 Fibrosis Antibodies  >20 publications with HAS2 and Fibrosis
 Atherosclerosis Antibodies  >17 publications with HAS2 and Atherosclerosis
 Neoplasm Invasiveness Antibodies  >17 publications with HAS2 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >16 publications with HAS2 and Neoplasm Metastasis
 Lung Diseases Antibodies  >14 publications with HAS2 and Lung Diseases
 Heart Diseases Antibodies  >13 publications with HAS2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >77 publications with HAS2 and Skin
 Bone Antibodies  >72 publications with HAS2 and Bone
 Muscle Antibodies  >50 publications with HAS2 and Muscle
 Vascular Antibodies  >49 publications with HAS2 and Vascular
 Embryonic Tissue Antibodies  >37 publications with HAS2 and Embryonic Tissue
 Lung Antibodies  >25 publications with HAS2 and Lung
 Bone Marrow Antibodies  >14 publications with HAS2 and Bone Marrow
 Thyroid Antibodies  >10 publications with HAS2 and Thyroid
 Cervix Antibodies  >5 publications with HAS2 and Cervix
 Liver Antibodies  >3 publications with HAS2 and Liver
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