CAB96612.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
96,718 Da
NCBI Official Full Name
hypoxia inducible factor 2 alpha
NCBI Official Synonym Full Names
endothelial PAS domain protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
endothelial PAS domain-containing protein 1; EPAS-1; HIF2 alpha; HIF2-alpha; HIF-2 alpha; HIF-2-alpha; hypoxia inducible factor 2a; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; hypoxia inducible factor 2, alpha subunit
UniProt Protein Name
Endothelial PAS domain-containing protein 1
UniProt Synonym Protein Names
Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha
UniProt Synonym Gene Names
UniProt Entry Name
EPAS1_RAT
NCBI Summary for HIF-2alpha
activates luciferase activity after transfection [RGD, Feb 2006]
UniProt Comments for HIF-2alpha
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD ().
Research Articles on HIF-2alpha
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Products associated with HIF-2alpha elisa kit
Pathways associated with HIF-2alpha elisa kit
Diseases associated with HIF-2alpha elisa kit
Organs/Tissues associated with HIF-2alpha elisa kit
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