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IFNG elisa kit :: Human IFN gamma ELISA Kit

Scan QR to view Datasheet Catalog #    MBS175910
 Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $305 +1 FREE 8GB USB
 
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 Product Name   

IFN gamma (IFNG), ELISA Kit

★Popular Item★
 Also Known As   

Human IFN gamma PicoKine ELISA Kit

 Product Synonym Names    Interferon gamma; interferon, gamma; IFG; IFI; IFN gamma; IFN Immune; IFNG; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; Type II Interferon
 Product Gene Name   

IFNG elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 609135
 3D Structure    ModBase 3D Structure for P01579
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 Species Reactivity    Human
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 Specificity    Natural and recombinant Human IFN Gamma
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 Assay Type    Quantitative Sandwich
 Detection Range    15.6pg/ml-1000pg/ml
 Sensitivity    <2pg/ml
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IFNG elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IFNG purchase    MBS175910 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IFN gamma (IFNG) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6pg/ml-1000pg/ml in biological research samples containing IFNG, with an estimated sensitivity of <2pg/ml. The ELISA analytical biochemical technique of the MBS175910 kit is based on IFNG antibody-IFNG antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFNG antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFNG. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IFNG elisa kit

   Principle of the Assay: Human IFN Gamma ELISA Kit was based on standard sandwich enzyme-linked immunesorbent assay technology. A monoclonal antibody from mouse specific for IFN Gamma has been precoated onto 96-well plates. Standards(Expression system for standard: E.coli; Immunogen sequence: Q24-Q166) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for IFN Gamma is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human IFN Gamma amount of sample captured in plate.

Background: Interferon-gamma(IFN-gamma) is an inflammatory cytokine that has been implicated in the development of fibrosis in inflamed tissues. The production of IFN-gamma, which is under genetic control, can influence the development of fibrosis in lung allografts. IFN-gamma is also produced by natural killer(NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Interferon gamma is believed to be crucial for host defence against many infections. Genetically determined variability in IFN-gamma and expression might be important for the development of tuberculosis. IFN-gamma activates human macrophage oxidative metabolism and antimicrobial activity. In addition to having antiviral activity, IFN-gamma has important immunoregulatory functions. IFN-gamma plays an important role in the control of neointima proliferation.
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  Typical Testing Data/Standard Curve (for reference only) of IFNG elisa kit    IFNG elisa kit  Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS175910. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IFNG. It may not necessarily be applicable to this product.
 NCBI GI #    124479
 NCBI GeneID    3458
 NCBI Accession #    P01579.1 [Other Products]
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 UniProt Primary Accession #    P01579 [Other Products]
 UniProt Secondary Accession #    Q53ZV4; B5BU88 [Other Products]
 UniProt Related Accession #    P01579 [Other Products]
 Molecular Weight    19,348 Da
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 NCBI Official Full Name    Interferon gamma
 NCBI Official Synonym Full Names    interferon, gamma
 NCBI Official Symbol    IFNG [Similar Products]
 NCBI Official Synonym Symbols   
IFG; IFI
[Similar Products]
 NCBI Protein Information    interferon gamma; IFN-gamma; immune interferon
 UniProt Protein Name    Interferon gamma
 UniProt Synonym Protein Names   
Immune interferon
 Protein Family    Interferon
 UniProt Gene Name    IFNG [Similar Products]
 UniProt Synonym Gene Names    IFN-gamma [Similar Products]
 UniProt Entry Name    IFNG_HUMAN
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 NCBI Summary for IFNG    This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
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 UniProt Comments for IFNG    IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Membrane protein, integral; Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: interferon-gamma receptor binding; cytokine activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; apoptosis; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; positive regulation of killing of cells of another organism; negative regulation of transcription from RNA polymerase II promoter; sensory perception of mechanical stimulus; positive regulation of interleukin-1 beta secretion; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; neutrophil chemotaxis; positive regulation of synaptic transmission, cholinergic; adaptive immune response; CD8-positive, alpha-beta T cell differentiation during immune response; negative regulation of myelination; unfolded protein response; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of tumor necrosis factor production; defense response to protozoan; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of interleukin-17 production; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; cell motility; positive regulation of neuron differentiation; regulation of insulin secretion

Disease: Hepatitis C Virus, Susceptibility To; Aplastic Anemia; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on IFNG    1. CASP has a direct role in the secretion of IFN-gamma, and NK cell motility and ability to kill tumor cells. CASP polarizes to the leading edge of migrating NK cells, and to the immunological synapse when engaged with tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFNG elisa kitPathways associated with IFNG elisa kit
 Reference Product  PubMed Publications
 CD4 elisa kit  >148 publications with IFNG and CD4
 IL2 elisa kit  >52 publications with IFNG and IL2
 TBX21 elisa kit  >51 publications with IFNG and TBX21
 STAT1 elisa kit  >37 publications with IFNG and STAT1
 IFNGR1 elisa kit  >29 publications with IFNG and IFNGR1
 IL18 elisa kit  >23 publications with IFNG and IL18
 IRF1 elisa kit  >16 publications with IFNG and IRF1
 CD86 elisa kit  >5 publications with IFNG and CD86
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
Diseases associated with IFNG elisa kitOrgans/Tissues associated with IFNG elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >142 publications with IFNG and Necrosis
 Autoimmune Diseases Antibodies  >85 publications with IFNG and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >66 publications with IFNG and Respiratory Tract Diseases
 Hepatitis Antibodies  >32 publications with IFNG and Hepatitis
 Lymphoproliferative Disorders Antibodies  >20 publications with IFNG and Lymphoproliferative Disorders
 Diabetes Mellitus, Type 1 Antibodies  >17 publications with IFNG and Diabetes Mellitus, Type 1
 HIV Infections Antibodies  >16 publications with IFNG and HIV Infections
 Arthritis, Rheumatoid Antibodies  >15 publications with IFNG and Arthritis, Rheumatoid
 Hepatitis C Antibodies  >14 publications with IFNG and Hepatitis C
 Leishmaniasis Antibodies  >9 publications with IFNG and Leishmaniasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >455 publications with IFNG and Blood
 Kidney Antibodies  >40 publications with IFNG and Kidney
 Lymph Node Antibodies  >24 publications with IFNG and Lymph Node
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