NP_001093326.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NF-kappa-B essential modulator isoform b
NCBI Official Synonym Full Names
inhibitor of nuclear factor kappa B kinase subunit gamma
NCBI Official Synonym Symbols
IP; IP1; IP2; FIP3; IKKG; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; IKKAP1; ZC2HC9; IKK-gamma [Similar Products]
NCBI Protein Information
NF-kappa-B essential modulator
UniProt Protein Name
NF-kappa-B essential modulator
UniProt Synonym Protein Names
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
UniProt Synonym Gene Names
FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma [Similar Products]
NCBI Summary for IKK-gamma
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
UniProt Comments for IKK-gamma
IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).
Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; cytosol; IkappaB kinase complex; intracellular; nucleus; spindle pole; ubiquitin ligase complex
Molecular Function: identical protein binding; linear polyubiquitin binding; metal ion binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; signal transducer activity; ubiquitin protein ligase binding
Biological Process: activation of MAPK activity; anoikis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptosis; cellular response to DNA damage stimulus; establishment of vesicle localization; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; immune response; inflammatory response; innate immune response; JNK cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of neuron death; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; regulation of tumor necrosis factor-mediated signaling pathway; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transcription, DNA-dependent; viral process
Disease: Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency 33; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Incontinentia Pigmenti; Invasive Pneumococcal Disease, Recurrent Isolated, 2
Research Articles on IKK-gamma
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Products associated with IKK-gamma elisa kit
Pathways associated with IKK-gamma elisa kit
Diseases associated with IKK-gamma elisa kit
Disease Name |
Pubmed Publications |
Incontinentia Pigmenti Antibodies |
>60 publications with IKK-gamma and Incontinentia Pigmenti |
Necrosis Antibodies |
>54 publications with IKK-gamma and Necrosis |
Inflammation Antibodies |
>32 publications with IKK-gamma and Inflammation |
Neoplasms Antibodies |
>25 publications with IKK-gamma and Neoplasms |
Carcinoma Antibodies |
>7 publications with IKK-gamma and Carcinoma |
Breast Neoplasms Antibodies |
>4 publications with IKK-gamma and Breast Neoplasms |
Liver Diseases Antibodies |
>4 publications with IKK-gamma and Liver Diseases |
Liver Neoplasms Antibodies |
>3 publications with IKK-gamma and Liver Neoplasms |
Neoplasms, Experimental Antibodies |
>3 publications with IKK-gamma and Neoplasms, Experimental |
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema Antibodies |
>2 publications with IKK-gamma and Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema |
Organs/Tissues associated with IKK-gamma elisa kit
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