NP_060023.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,753 Da
NCBI Official Full Name
DNA helicase INO80
NCBI Official Synonym Full Names
INO80 complex subunit
NCBI Protein Information
DNA helicase INO80; INO80 homolog; homolog of yeast INO80; INO80 complex subunit A; putative DNA helicase INO80 complex homolog 1
UniProt Protein Name
DNA helicase INO80
UniProt Synonym Protein Names
INO80 complex subunit A; Putative DNA helicase INO80 complex homolog 1
UniProt Synonym Gene Names
UniProt Entry Name
INO80_HUMAN
NCBI Summary for INO80
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for INO80
INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.
Protein type: DNA-binding; Helicase; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: microtubule; nucleus
Molecular Function: DNA helicase activity; protein binding; DNA binding; ATPase activity; actin binding; ATP binding; alpha-tubulin binding
Biological Process: chromatin remodeling; mitotic sister chromatid segregation; cell division; double-strand break repair; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; positive regulation of cell growth; double-strand break repair via homologous recombination; DNA duplex unwinding
Research Articles on INO80
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Diseases associated with INO80 elisa kit
Organs/Tissues associated with INO80 elisa kit
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