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INSL3 elisa kit :: Human INSL3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2502152
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INSL3, ELISA Kit

★Popular Item★
 Also Known As   

Human INSL3(Insulin Like Protein 3)ELISA Kit

 Product Gene Name   

INSL3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    146738
 3D Structure    ModBase 3D Structure for P51460
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human INSL3. No significant cross-reactivity or interference between Human INSL3 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human INSL3 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of INSL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for INSL3 purchase    MBS2502152 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the INSL3, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing INSL3, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2502152 kit is based on INSL3 antibody-INSL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect INSL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, INSL3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for INSL3 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of INSL3 in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human INSL3. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human INSL3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human INSL3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human INSL3. You can calculate the concentration of Human INSL3 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of INSL3 elisa kit    INSL3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2502152. Click to request current manual
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NCBI/Uniprot data below describe general gene information for INSL3. It may not necessarily be applicable to this product.
 NCBI GI #    388240756
 NCBI GeneID    3640
 NCBI Accession #    NP_001252516.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001265587.1 [Other Products]
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 UniProt Primary Accession #    P51460 [Other Products]
 UniProt Secondary Accession #    Q3KPI5; Q3KPI6; Q6YNB5; Q9UEA2; Q9UPH6; B4DZ72; G3XAG0 [Other Products]
 UniProt Related Accession #    P51460 [Other Products]
 Molecular Weight    16,872 Da
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 NCBI Official Full Name    insulin-like 3 isoform 1
 NCBI Official Synonym Full Names    insulin-like 3 (Leydig cell)
 NCBI Official Symbol    INSL3 [Similar Products]
 NCBI Official Synonym Symbols   
RLF; RLNL; ley-I-L
[Similar Products]
 NCBI Protein Information    insulin-like 3; leydig insulin -like hormone; leydig insulin-like peptide; prepro-INSL3; relaxin-like factor b
 UniProt Protein Name    Insulin-like 3
 UniProt Synonym Protein Names   
Leydig insulin-like peptide; Ley-I-L; Relaxin-like factorCleaved into the following 2 chains:Insulin-like 3 B chain; Insulin-like 3 A chain
 Protein Family    Insulin
 UniProt Gene Name    INSL3 [Similar Products]
 UniProt Synonym Gene Names    RLF; RLNL; Ley-I-L [Similar Products]
 UniProt Entry Name    INSL3_HUMAN
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 NCBI Summary for INSL3    This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
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 UniProt Comments for INSL3    INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.2-p12

Cellular Component: extracellular space; perinuclear region of cytoplasm; extracellular region

Molecular Function: G-protein-coupled receptor binding; protease binding; hormone activity; insulin receptor binding; receptor binding

Biological Process: negative regulation of cell proliferation; cell-cell signaling; in utero embryonic development; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; male gonad development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; oocyte maturation; negative regulation of apoptosis

Disease: Cryptorchidism, Unilateral Or Bilateral
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 Research Articles on INSL3    1. low INSL3 concentration is related to the pathogenesis behind an unfavourable change in body composition and bone metabolism among Klinefelter syndrome patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with INSL3 elisa kitPathways associated with INSL3 elisa kit
 Reference Product  PubMed Publications
 RXFP2 elisa kit  >97 publications with INSL3 and RXFP2
 RXFP1 elisa kit  >39 publications with INSL3 and RXFP1
 INSL6 elisa kit  >11 publications with INSL3 and INSL6
 RLN3 elisa kit  >9 publications with INSL3 and RLN3
 RXFP4 elisa kit  >7 publications with INSL3 and RXFP4
 INSL4 elisa kit  >7 publications with INSL3 and INSL4
 RLN1 elisa kit  >5 publications with INSL3 and RLN1
 NR4A1 elisa kit  >4 publications with INSL3 and NR4A1
 IDE elisa kit  >2 publications with INSL3 and IDE
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Relaxin Receptors Pathway antibodies  Relaxin Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with INSL3 elisa kitOrgans/Tissues associated with INSL3 elisa kit
 Disease Name  Pubmed Publications
 Cryptorchidism Antibodies  >121 publications with INSL3 and Cryptorchidism
 Gonadal Disorders Antibodies  >107 publications with INSL3 and Gonadal Disorders
 Genital Diseases, Male Antibodies  >101 publications with INSL3 and Genital Diseases, Male
 Urogenital Abnormalities Antibodies  >98 publications with INSL3 and Urogenital Abnormalities
 Testicular Diseases Antibodies  >91 publications with INSL3 and Testicular Diseases
 Infertility, Male Antibodies  >36 publications with INSL3 and Infertility, Male
 Disorders of Sex Development Antibodies  >22 publications with INSL3 and Disorders of Sex Development
 Prenatal Exposure Delayed Effects Antibodies  >12 publications with INSL3 and Prenatal Exposure Delayed Effects
 Infertility, Female Antibodies  >12 publications with INSL3 and Infertility, Female
 Hyperplasia Antibodies  >7 publications with INSL3 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >194 publications with INSL3 and Testis
 Blood Antibodies  >66 publications with INSL3 and Blood
 Brain Antibodies  >15 publications with INSL3 and Brain
 Placenta Antibodies  >6 publications with INSL3 and Placenta
 Eye Antibodies  >1 publications with INSL3 and Eye
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