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IgG4 elisa kit :: Human Immunoglobulin G4 (IgG4) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS703648
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $625 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,595 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,905 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Immunoglobulin G4 (IgG4), ELISA Kit

 Also Known As   

Human Immunoglobulin G4 (IgG4) ELISA Kit

 Product Synonym Names    Immunoglobulin G4 (IgG4)
 Product Gene Name   

IgG4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS703648 Testing Data    Testing Data PDF
 Chromosome Location    Chromosome: 2; NC_000002.11 (204801471..204826300). Location: 2q33
 3D Structure    ModBase 3D Structure for Q53QY6
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 Species Reactivity    Human
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 Samples    Serum, plasma
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IgG4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IgG4 purchase    MBS703648 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Immunoglobulin G4 (IgG4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IgG4. The ELISA analytical biochemical technique of the MBS703648 kit is based on IgG4 antibody-IgG4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IgG4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IgG4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IgG4 elisa kit

   Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with human IgG4. Standards or samples are then added to the appropriate microtiter plate wells with Horseradish Peroxidase (HRP) -conjugated antibody preparation specific for human IgG4, mix well and incubated. The more the amount of human IgG4 in samples, the less HRP-antibody bound by pre-coated human IgG4. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. And the color develops in opposite to the amount of human IgG4 in the sample. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of IgG4 elisa kit    IgG4 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS703648. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IgG4. It may not necessarily be applicable to this product.
 NCBI GI #    15029518
 NCBI GeneID    29851
 NCBI Accession #    NP_036224.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012092.3 [Other Products]
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 UniProt Primary Accession #    Q53QY6 [Other Products]
 UniProt Related Accession #    Q53QY6; Q9Y6W8 [Other Products]
 Molecular Weight    22,625 Da
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 NCBI Official Full Name    inducible T-cell costimulator
 NCBI Official Synonym Full Names    inducible T-cell co-stimulator
 NCBI Official Symbol    ICOS [Similar Products]
 NCBI Official Synonym Symbols   
AILIM; CD278; CVID1
[Similar Products]
 NCBI Protein Information    inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule
 UniProt Protein Name    Inducible T-cell co-stimulator
 UniProt Gene Name    ICOS [Similar Products]
 UniProt Entry Name    Q53QY6_HUMAN
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 NCBI Summary for IgG4    The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IgG4    ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; external side of plasma membrane

Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1
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 Research Articles on IgG4    1. ICOS gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IgG4 elisa kitPathways associated with IgG4 elisa kit
 Reference Product  PubMed Publications
 ICOSLG elisa kit  >45 publications with IgG4 and ICOSLG
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with IgG4 elisa kitOrgans/Tissues associated with IgG4 elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >264 publications with IgG4 and Immune System Diseases
 Inflammation Antibodies  >121 publications with IgG4 and Inflammation
 Neoplasms Antibodies  >69 publications with IgG4 and Neoplasms
 Hypersensitivity Antibodies  >52 publications with IgG4 and Hypersensitivity
 Asthma Antibodies  >41 publications with IgG4 and Asthma
 Common Variable Immunodeficiency Antibodies  >40 publications with IgG4 and Common Variable Immunodeficiency
 Respiratory Hypersensitivity Antibodies  >33 publications with IgG4 and Respiratory Hypersensitivity
 Diabetes Mellitus Antibodies  >30 publications with IgG4 and Diabetes Mellitus
 Virus Diseases Antibodies  >30 publications with IgG4 and Virus Diseases
 Respiratory Tract Infections Antibodies  >19 publications with IgG4 and Respiratory Tract Infections
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >632 publications with IgG4 and Blood
 Lung Antibodies  >46 publications with IgG4 and Lung
 Heart Antibodies  >37 publications with IgG4 and Heart
 Brain Antibodies  >24 publications with IgG4 and Brain
 Thymus Antibodies  >18 publications with IgG4 and Thymus
 Pharynx Antibodies  >9 publications with IgG4 and Pharynx
 Thyroid Antibodies  >7 publications with IgG4 and Thyroid
 Uterus Antibodies  >2 publications with IgG4 and Uterus
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