NP_001180250.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,816 Da
NCBI Official Full Name
inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
NCBI Official Synonym Full Names
inhibitor of nuclear factor kappa B kinase subunit epsilon
NCBI Protein Information
inhibitor of nuclear factor kappa-B kinase subunit epsilon
UniProt Protein Name
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
UniProt Synonym Protein Names
Inducible I kappa-B kinase; IKK-i
UniProt Synonym Gene Names
IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i [Similar Products]
NCBI Summary for IKBKE
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
UniProt Comments for IKBKE
IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.
Protein type: EC 2.7.11.10; IKK family; Inhibitor; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: cytoplasm; cytosol; endosome membrane; mitochondrial membrane; nucleus; PML body
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; ubiquitin protein ligase binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; innate immune response; negative regulation of interferon type I production; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid phosphorylation; protein homooligomerization
Research Articles on IKBKE
Precautions
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Products associated with IKBKE elisa kit
Pathways associated with IKBKE elisa kit
Diseases associated with IKBKE elisa kit
Organs/Tissues associated with IKBKE elisa kit
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