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ITGa6 elisa kit :: Human Integrin Alpha 6 (ITGa6) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2020560 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $260 +1 FREE 8GB USB
48-Strip-Wells  /  $475 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,590 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,670 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin Alpha 6 (ITGa6), ELISA Kit

★Popular Item★
 Also Known As   

Integrin Alpha 6 (ITGa6) ELISA Kit

 Product Synonym Names    CD49f; CD49-F; ITG-A6; ITGA6B; VLA-6; CD49 antigen-like family member F; Processed integrin alpha-6
 Product Gene Name   

ITGa6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    147556
 3D Structure    ModBase 3D Structure for P23229
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Integrin Alpha 6 (ITGa6).
No significant cross-reactivity or interference between Integrin Alpha 6 (ITGa6) and analogues was observed.
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 Assay Type    Double-antibody Sandwich
 Samples    Tissue homogenates, Cell lysates and Other Biological Fluids
 Detection Range    0.156-10ng/mL
 Sensitivity    < 0.057ng/mL
 Application    Enzyme-linked immunosorbent assay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level Integrin Alpha 6 (ITGa6) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level Integrin Alpha 6 (ITGa6) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ITGa6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ITGa6 purchase    MBS2020560 is a ready-to-use microwell, strip plate Double-antibody Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Integrin Alpha 6 (ITGa6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing ITGa6, with an estimated sensitivity of < 0.057ng/mL. The ELISA analytical biochemical technique of the MBS2020560 kit is based on ITGa6 antibody-ITGa6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ITGa6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ITGa6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Tissue homogenates, Cell lysates and Other Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ITGa6 elisa kit

   The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Integrin Alpha 6 (ITGa6). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Integrin Alpha 6 (ITGa6). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Integrin Alpha 6 (ITGa6), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Integrin Alpha 6 (ITGa6) in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Product Categories/Family for ITGa6 elisa kit    CD & Adhesion molecule
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 Typical Testing Data/Standard Curve (for reference only) of ITGa6 elisa kit    ITGa6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2020560. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ITGa6. It may not necessarily be applicable to this product.
 NCBI GI #    5726563
 NCBI GeneID    3655
 NCBI Accession #    AAD48469.1 [Other Products]
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 UniProt Primary Accession #    P23229 [Other Products]
 UniProt Secondary Accession #    Q08443; Q0MRC7; Q14646; Q16508; Q53RX7; Q59HB7; B2RMU9; B4DG69; B4DKB8; C4AM96; G5E9H1 [Other Products]
 UniProt Related Accession #    P23229 [Other Products]
 Molecular Weight    122,358 Da
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 NCBI Official Full Name    integrin alpha 6
 NCBI Official Synonym Full Names    integrin, alpha 6
 NCBI Official Symbol    ITGA6 [Similar Products]
 NCBI Official Synonym Symbols   
CD49f; VLA-6; ITGA6B
[Similar Products]
 NCBI Protein Information    integrin alpha-6
 UniProt Protein Name    Integrin alpha-6
 UniProt Synonym Protein Names   
CD49 antigen-like family member F; VLA-6; CD_antigen: CD49f
 Protein Family    Integrin
 UniProt Gene Name    ITGA6 [Similar Products]
 UniProt Synonym Gene Names    Alpha6p [Similar Products]
 UniProt Entry Name    ITA6_HUMAN
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 NCBI Summary for ITGa6    The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGa6    ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: focal adhesion; cell-cell adherens junction; cell surface; hemidesmosome; basal plasma membrane; plasma membrane; basement membrane; filopodium; external side of plasma membrane

Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding

Biological Process: integrin-mediated signaling pathway; skin development; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; hemidesmosome assembly; cell-cell adhesion; gut development; cell-substrate junction assembly; cellular response to extracellular stimulus; brown fat cell differentiation; positive regulation of cell-cell adhesion; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
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 Research Articles on ITGa6    1. ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ITGa6 elisa kitDiseases associated with ITGa6 elisa kit
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Epidermolysis bullosa with pyloric atresia Antibodies  >11 publications with ITGa6 and Epidermolysis bullosa with pyloric atresia
 Neoplasm Metastasis Antibodies  >7 publications with ITGa6 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >7 publications with ITGa6 and Breast Neoplasms
 Fibrosis Antibodies  >5 publications with ITGa6 and Fibrosis
 Prostatic Diseases Antibodies  >4 publications with ITGa6 and Prostatic Diseases
 Inflammation Antibodies  >4 publications with ITGa6 and Inflammation
 Neoplasm Invasiveness Antibodies  >4 publications with ITGa6 and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >3 publications with ITGa6 and Liver Neoplasms
 Prostatic Neoplasms Antibodies  >3 publications with ITGa6 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with ITGa6 and Neoplasms, Experimental
Organs/Tissues associated with ITGa6 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >21 publications with ITGa6 and Skin
 Testis Antibodies  >12 publications with ITGa6 and Testis
 Stomach Antibodies  >10 publications with ITGa6 and Stomach
 Blood Antibodies  >10 publications with ITGa6 and Blood
 Prostate Antibodies  >9 publications with ITGa6 and Prostate
 Bone Antibodies  >7 publications with ITGa6 and Bone
 Vascular Antibodies  >5 publications with ITGa6 and Vascular
 Liver Antibodies  >5 publications with ITGa6 and Liver
 Brain Antibodies  >5 publications with ITGa6 and Brain
 Mouth Antibodies  >4 publications with ITGa6 and Mouth
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