NP_000202.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,782 Da
NCBI Official Full Name
integrin beta-2 isoform 1
NCBI Official Synonym Full Names
integrin subunit beta 2
NCBI Official Synonym Symbols
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 [Similar Products]
NCBI Protein Information
integrin beta-2
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
UniProt Synonym Gene Names
UniProt Entry Name
ITB2_HUMAN
NCBI Summary for ITGB2
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for ITGB2
ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Cell surface; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cell surface; integrin complex; membrane; plasma membrane; receptor complex
Molecular Function: cell adhesion molecule binding; glycoprotein binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase binding
Biological Process: activation of NF-kappaB transcription factor; aging; apoptosis; blood coagulation; cell adhesion; cell-cell signaling; cell-matrix adhesion; cellular extravasation; endothelial cell migration; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte migration during inflammatory response; natural killer cell activation; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; receptor clustering; receptor internalization; regulation of cell shape; regulation of immune response; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway
Disease: Leukocyte Adhesion Deficiency, Type I
Research Articles on ITGB2
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Products associated with ITGB2 elisa kit
Pathways associated with ITGB2 elisa kit
Diseases associated with ITGB2 elisa kit
Organs/Tissues associated with ITGB2 elisa kit
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