NP_002192.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,199 Da
NCBI Official Full Name
interferon-stimulated gene 20 kDa protein
NCBI Official Synonym Full Names
interferon stimulated exonuclease gene 20kDa
NCBI Official Synonym Symbols
NCBI Protein Information
interferon-stimulated gene 20 kDa protein; estrogen-regulated transcript 45 protein; promyelocytic leukemia nuclear body-associated protein ISG20
UniProt Protein Name
Interferon-stimulated gene 20 kDa protein
UniProt Synonym Protein Names
Estrogen-regulated transcript 45 protein; Promyelocytic leukemia nuclear body-associated protein ISG20
UniProt Synonym Gene Names
UniProt Entry Name
ISG20_HUMAN
UniProt Comments for ISG20
ISG20: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses. Belongs to the exonuclease superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Deoxyribonuclease; Ribonuclease; EC 3.1.13.1; Nucleolus
Chromosomal Location of Human Ortholog: 15q26
Cellular Component: nucleoplasm; Cajal body; PML body; cytoplasm; nucleolus; nucleus
Molecular Function: exoribonuclease II activity; 3'-5'-exoribonuclease activity; U1 snRNA binding; metal ion binding; exonuclease activity; single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; U2 snRNA binding
Biological Process: cell proliferation; negative regulation of viral genome replication; response to virus; cytokine and chemokine mediated signaling pathway; RNA catabolic process; DNA catabolic process, exonucleolytic; defense response to virus; rRNA processing
Research Articles on ISG20
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Products associated with ISG20 elisa kit
Pathways associated with ISG20 elisa kit
Diseases associated with ISG20 elisa kit
Organs/Tissues associated with ISG20 elisa kit
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