AAG40848.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,523 Da
NCBI Official Full Name
interleukin 17E
NCBI Official Synonym Full Names
interleukin 25
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-25; interleukin-17E
UniProt Protein Name
Interleukin-25
UniProt Synonym Protein Names
Interleukin-17E; IL-17E
UniProt Synonym Gene Names
UniProt Entry Name
IL25_HUMAN
NCBI Summary for IL 17E
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for IL 17E
IL25: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Belongs to the IL-17 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: extracellular space
Molecular Function: cytokine activity; interleukin-17E receptor binding
Biological Process: response to fungus; inflammatory response to antigenic stimulus; response to nematode; eosinophil differentiation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on IL 17E
Precautions
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Products associated with IL 17E elisa kit
Pathways associated with IL 17E elisa kit
Diseases associated with IL 17E elisa kit
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