NP_000869.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,117 Da
NCBI Official Full Name
interleukin-2 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 2 receptor subunit beta
NCBI Protein Information
interleukin-2 receptor subunit beta
UniProt Protein Name
Interleukin-2 receptor subunit beta
UniProt Synonym Protein Names
High affinity IL-2 receptor subunit beta; p70-75; p75; CD_antigen: CD122
UniProt Synonym Gene Names
UniProt Entry Name
IL2RB_HUMAN
NCBI Summary for IL2RB
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
UniProt Comments for IL2RB
IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: external side of plasma membrane; integral to plasma membrane; intracellular; membrane; plasma membrane
Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; protein binding
Biological Process: activation of MAPKK activity; axon guidance; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; protein complex assembly; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; viral reproduction
Research Articles on IL2RB
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Products associated with IL2RB elisa kit
Pathways associated with IL2RB elisa kit
Diseases associated with IL2RB elisa kit
Organs/Tissues associated with IL2RB elisa kit
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