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KYNU elisa kit :: Human Kynureninase (KYNU) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2600302
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kynureninase (KYNU), ELISA Kit

★Popular Item★
 Also Known As   

Human Kynureninase (KYNU) ELISA Kit

 Product Gene Name   

KYNU elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant KYNU concentration
 Assay Type    Sandwich
 Detection Range    10 ng/ml-0.156 ng/ml
 Sensitivity    0.05 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KYNU elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KYNU purchase    MBS2600302 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Kynureninase (KYNU) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 ng/ml-0.156 ng/ml in biological research samples containing KYNU, with an estimated sensitivity of 0.05 ng/ml. The ELISA analytical biochemical technique of the MBS2600302 kit is based on KYNU antibody-KYNU antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KYNU antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KYNU. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant KYNU concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for KYNU elisa kit

   Principle of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human KYNU monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of KYNU elisa kit    KYNU elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2600302. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KYNU. It may not necessarily be applicable to this product.
 NCBI GI #    16758776
 NCBI GeneID    116682
 NCBI Accession #    NP_446354.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053902.2 [Other Products]
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 UniProt Secondary Accession #    Q68G25; Q7M0D0; Q9QW90 [Other Products]
 UniProt Related Accession #    P70712 [Other Products]
 Molecular Weight    52,470 Da
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 NCBI Official Full Name    kynureninase
 NCBI Official Synonym Full Names    kynureninase
 NCBI Official Symbol    Kynu [Similar Products]
 NCBI Protein Information    kynureninase; L-kynurenine hydrolase
 UniProt Protein Name    Kynureninase
 UniProt Synonym Protein Names   
L-kynurenine hydrolase
 UniProt Gene Name    Kynu [Similar Products]
 UniProt Entry Name    KYNU_RAT
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 NCBI Summary for KYNU    enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006]
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 UniProt Comments for KYNU    KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Mitochondrial; Amino Acid Metabolism - tryptophan; EC 3.7.1.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding

Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process
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 Research Articles on KYNU    1. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with KYNU elisa kitDiseases associated with KYNU elisa kit
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Degradation III (eukaryotic) Pathway antibodies  Tryptophan Degradation III (eukaryotic) Pathway Diagram
 Tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  Tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
 Tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  Tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with KYNU and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with KYNU and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with KYNU and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with KYNU and Congenital Abnormalities
 Necrosis Antibodies  >1 publications with KYNU and Necrosis
 Hydroxykynureninuria Antibodies  >1 publications with KYNU and Hydroxykynureninuria
Organs/Tissues associated with KYNU elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with KYNU and Liver
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