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LEMD3 elisa kit :: Human LEM domain containing 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9330215 LEMD3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LEM domain containing 3 (LEMD3), ELISA Kit

 Also Known As   

Human Inner nuclear membrane protein Man1, LEMD3 ELISA Kit

 Product Synonym Names    Human Inner nuclear membrane protein Man1 (LEMD3) ELISA kit; MAN1; integral inner nuclear membrane protein; LEM domain containing 3
 Product Gene Name   

LEMD3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607844
 3D Structure    ModBase 3D Structure for Q9Y2U8
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LEMD3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LEMD3 purchase    MBS9330215 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the LEM domain containing 3 (LEMD3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LEMD3. The ELISA analytical biochemical technique of the MBS9330215 kit is based on LEMD3 antibody-LEMD3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LEMD3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LEMD3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LEMD3. It may not necessarily be applicable to this product.
 NCBI GI #    264681410
 NCBI GeneID    23592
 NCBI Accession #    NP_001161086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001167614.1 [Other Products]
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 UniProt Primary Accession #    Q9Y2U8 [Other Products]
 UniProt Secondary Accession #    Q9NT47; Q9NYA5 [Other Products]
 UniProt Related Accession #    Q9Y2U8 [Other Products]
 Molecular Weight    99,997 Da
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 NCBI Official Full Name    inner nuclear membrane protein Man1 isoform 2
 NCBI Official Synonym Full Names    LEM domain containing 3
 NCBI Official Symbol    LEMD3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    inner nuclear membrane protein Man1; LEM domain-containing protein 3; integral inner nuclear membrane protein
 UniProt Protein Name    Inner nuclear membrane protein Man1
 UniProt Synonym Protein Names   
LEM domain-containing protein 3
 Protein Family    Inner nuclear membrane protein
 UniProt Gene Name    LEMD3 [Similar Products]
 UniProt Synonym Gene Names    MAN1 [Similar Products]
 UniProt Entry Name    MAN1_HUMAN
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 NCBI Summary for LEMD3    This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
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 UniProt Comments for LEMD3    MAN1: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Defects in LEMD3 are the cause of Buschke-Ollendorff syndrome (BOS); also known as dermatoosteopoikilosis or disseminated dermatofibrosis with osteopoikilosis or dermatofibrosis lenticularis disseminata with osteopoikilosis or osteopathia condensans disseminata. BOS refers to the association of osteopoikilosis with disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Both elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both. Defects in LEMD3 are a cause of melorheostosis (MEL). Melorheostosis is a rare mesenchymal dysplasia and one of the sclerosing bone disorders. It is caused by a developmental error, with a sclerotomal distribution, frequently involving one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: membrane; integral to membrane; nuclear inner membrane; integral to nuclear inner membrane

Molecular Function: protein binding; DNA binding; nucleotide binding

Biological Process: blood vessel endothelial cell migration during intussusceptive angiogenesis; negative regulation of activin receptor signaling pathway; regulation of cell cycle; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear organization and biogenesis; negative regulation of BMP signaling pathway

Disease: Buschke-ollendorff Syndrome; Melorheostosis, Isolated
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 Research Articles on LEMD3    1. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LEMD3 elisa kitDiseases associated with LEMD3 elisa kit
 Reference Product  PubMed Publications
 SMAD2 elisa kit  >2 publications with LEMD3 and SMAD2
 Disease Name  Pubmed Publications
 Bone Diseases, Developmental Antibodies  >17 publications with LEMD3 and Bone Diseases, Developmental
 Buschke-Ollendorff syndrome Antibodies  >14 publications with LEMD3 and Buschke-Ollendorff syndrome
 Melorheostosis Antibodies  >11 publications with LEMD3 and Melorheostosis
 Chromosome Aberrations Antibodies  >6 publications with LEMD3 and Chromosome Aberrations
 Congenital Abnormalities Antibodies  >6 publications with LEMD3 and Congenital Abnormalities
 Learning Disorders Antibodies  >2 publications with LEMD3 and Learning Disorders
 Craniofacial Abnormalities Antibodies  >2 publications with LEMD3 and Craniofacial Abnormalities
 Scoliosis Antibodies  >1 publications with LEMD3 and Scoliosis
 Heart Defects, Congenital Antibodies  >1 publications with LEMD3 and Heart Defects, Congenital
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