Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow LGMN rightarrow Human LGMN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • R-Spondin 1 (RSPO1) Recombinant Protein
 • BAD Antibody
 • scavenger receptor class F, member 1 (SCARF1) ELISA Kit
 • CamKII, phosphorylated Antibody
 • Myelin protein P0 (MPZ) Recombinant Protein
 • IL-1beta ELISA Kit
 • Interferon Gamma (IFNg) Recombinant Protein
 • Insulin Like Growth Factor Binding Protein 1 (IGFBP1) ELISA Kit
 • Tissue, Section Disease, Alzheimer's Disease, Brain, Hippoca... Tissue Section
 • Mitochondria Isolation Kit For Tissue & Cultured Cells Assay Kit
 • SFTPA2 (SFTPA1) Antibody
 • Osteocalcin (BGLAP) Recombinant Protein
 • Apolipoprotein B-100 (Apob) ELISA Kit
 • zonulin ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

LGMN elisa kit :: Human Legumain (LGMN) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS451078
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $400 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,425 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,710 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Legumain (LGMN), ELISA Kit

★Popular Item★
 Also Known As   

Human Legumain (LGMN) ELISA Kit

 Product Synonym Names    AEP; LGMN1; PRSC1; Protease,Cysteine 1; Asparaginyl endopeptidase
 Product Gene Name   

LGMN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS451078 COA    COA PDF
 OMIM    Y09862 mRNA
 3D Structure    ModBase 3D Structure for Q99538
Section Bar
 Species Reactivity    Human
Section Bar
Section Bar
 Samples    Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
 Assay Type    Sandwich
 Detection Range    0.312-20ng/mL
 Sensitivity    0.118ng/mL
 Intra Assay    CV<10%
 Inter Assay    CV<12%
Section Bar
 Preparation and Storage    For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LGMN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LGMN purchase    MBS451078 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Legumain (LGMN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312-20ng/mL in biological research samples containing LGMN, with an estimated sensitivity of 0.118ng/mL. The ELISA analytical biochemical technique of the MBS451078 kit is based on LGMN antibody-LGMN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LGMN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LGMN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates and other biological fluids. . Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
Section Bar
 Typical Testing Data/Standard Curve (for reference only) of LGMN elisa kit    LGMN elisa kit Typical Testing Data/Standard Curve (for reference only) image
Table BarTOPTable Bar
Sample Manual Insert of MBS451078. Click to request current manual
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for LGMN. It may not necessarily be applicable to this product.
 NCBI GI #    56682964
 NCBI GeneID    5641
 NCBI Accession #    NP_001008530.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008530.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q99538 [Other Products]
 UniProt Secondary Accession #    O00123; Q86TV2; Q86TV3; Q9BTY1 [Other Products]
 UniProt Related Accession #    Q99538 [Other Products]
 Molecular Weight    42,008 Da
Table BarTOPTable Bar
 NCBI Official Full Name    legumain preproprotein
 NCBI Official Synonym Full Names    legumain
 NCBI Official Symbol    LGMN [Similar Products]
 NCBI Official Synonym Symbols   
AEP; LGMN1; PRSC1
[Similar Products]
 NCBI Protein Information    legumain
 UniProt Protein Name    Legumain
 UniProt Synonym Protein Names   
Asparaginyl endopeptidase; Protease, cysteine 1
 UniProt Gene Name    LGMN [Similar Products]
 UniProt Synonym Gene Names    PRSC1 [Similar Products]
Section Bar
 NCBI Summary for LGMN    This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for LGMN    Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Table BarTOPTable Bar
 Research Articles on LGMN    1. upregulation of legumain is associated with malignant behavior of uveal melanoma.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with LGMN elisa kitPathways associated with LGMN elisa kit
 Reference Product  PubMed Publications
 CTSS elisa kit  >1 publications with LGMN and CTSS
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
Diseases associated with LGMN elisa kitOrgans/Tissues associated with LGMN elisa kit
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with LGMN and Breast Neoplasms
 Prenatal Injuries Antibodies  >1 publications with LGMN and Prenatal Injuries
 Liver Neoplasms Antibodies  >1 publications with LGMN and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with LGMN and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with LGMN and Liver Diseases
 Fibrosis Antibodies  >1 publications with LGMN and Fibrosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with LGMN and Prenatal Exposure Delayed Effects
 Inflammation Antibodies  >1 publications with LGMN and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with LGMN and Blood
 Embryonic Tissue Antibodies  >3 publications with LGMN and Embryonic Tissue
 Uterus Antibodies  >2 publications with LGMN and Uterus
 Nerve Antibodies  >1 publications with LGMN and Nerve
 Vascular Antibodies  >1 publications with LGMN and Vascular
 Umbilical Cord Antibodies  >1 publications with LGMN and Umbilical Cord
 Pancreas Antibodies  >1 publications with LGMN and Pancreas
 Liver Antibodies  >1 publications with LGMN and Liver
 Kidney Antibodies  >1 publications with LGMN and Kidney
 Brain Antibodies  >1 publications with LGMN and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions