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LNPEP elisa kit :: Human Leucyl-Cystinyl Aminopeptidase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS007258 LNPEP elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leucyl-Cystinyl Aminopeptidase (LNPEP), ELISA Kit

 Also Known As   

Human Leucyl-Cystinyl Aminopeptidase ELISA Kit

 Product Gene Name   

LNPEP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 5; NC_000005.9 (96271346..96365115). Location: 5q15
 OMIM    151300
 3D Structure    ModBase 3D Structure for Q9UIQ6
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 Species Reactivity    Human
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LNPEP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LNPEP purchase    MBS007258 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Leucyl-Cystinyl Aminopeptidase (LNPEP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LNPEP. The ELISA analytical biochemical technique of the MBS007258 kit is based on LNPEP antibody-LNPEP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LNPEP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LNPEP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LNPEP. It may not necessarily be applicable to this product.
 NCBI GI #    61742777
 NCBI GeneID    4012
 NCBI Accession #    NP_005566.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005575.2 [Other Products]
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 UniProt Primary Accession #    Q9UIQ6 [Other Products]
 UniProt Secondary Accession #    O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ7 [Other Products]
 UniProt Related Accession #    Q9UIQ6 [Other Products]
 Molecular Weight    117,349 Da
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 NCBI Official Full Name    leucyl-cystinyl aminopeptidase isoform 1
 NCBI Official Synonym Full Names    leucyl/cystinyl aminopeptidase
 NCBI Official Symbol    LNPEP [Similar Products]
 NCBI Official Synonym Symbols   
CAP; IRAP; PLAP; P-LAP
[Similar Products]
 NCBI Protein Information    leucyl-cystinyl aminopeptidase; otase; oxytocinase; vasopressinase; AT (4) receptor; angiotensin IV receptor; insulin-regulated aminopeptidase; placental leucine aminopeptidase; insulin-responsive aminopeptidase; insulin-regulated membrane aminopeptidase
 UniProt Protein Name    Leucyl-cystinyl aminopeptidase
 UniProt Synonym Protein Names   
Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; Oxytocinase; OTase; Placental leucine aminopeptidase
 Protein Family    Leucyl-cystinyl aminopeptidase
 UniProt Gene Name    LNPEP [Similar Products]
 UniProt Synonym Gene Names    OTASE; Cystinyl aminopeptidase; IRAP; OTase; P-LAP [Similar Products]
 UniProt Entry Name    LCAP_HUMAN
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 NCBI Summary for LNPEP    This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LNPEP    IRAP: a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described.

Protein type: EC 3.4.11.3; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: cytoplasmic vesicle membrane; membrane; perinuclear region of cytoplasm; lysosomal membrane; integral to plasma membrane; extracellular region; plasma membrane; intracellular; cytosol

Molecular Function: zinc ion binding; metallopeptidase activity; aminopeptidase activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; cell-cell signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein catabolic process; female pregnancy; proteolysis
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 Research Articles on LNPEP    1. S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with LNPEP elisa kitDiseases associated with LNPEP elisa kit
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Endosomal/Vacuolar Pathway antibodies  Endosomal/Vacuolar Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Insulin-mediated Glucose Transport Pathway antibodies  Insulin-mediated Glucose Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with LNPEP and Inflammation
 Atrophy Antibodies  >1 publications with LNPEP and Atrophy
 Brain Diseases Antibodies  >1 publications with LNPEP and Brain Diseases
 Necrosis Antibodies  >1 publications with LNPEP and Necrosis
Organs/Tissues associated with LNPEP elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with LNPEP and Blood
 Brain Antibodies  >2 publications with LNPEP and Brain
 Skin Antibodies  >1 publications with LNPEP and Skin
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