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LRP2 elisa kit :: Human Low Density Lipoprotein Receptor Related Protein 2 (LRP2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2023773 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $270 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $665 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,715 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,895 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Low Density Lipoprotein Receptor Related Protein 2 (LRP2), ELISA Kit

★Popular Item★
 Also Known As   

Low Density Lipoprotein Receptor Related Protein 2 (LRP2) ELISA Kit

 Product Synonym Names    DBS; gp330; Glycoprotein 330; Megalin; Low Density Lipoprotein-Related Protein 2
 Product Gene Name   

LRP2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    222448
 3D Structure    ModBase 3D Structure for P98164
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of LRP2. No significant cross-reactivity or interference between LRP2 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    31.2-2,000pg/mL
 Sensitivity    14.2pg/mL
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level LRP2 were tested 20 times on one plate, respectively. Intra-Assay: CV<10%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level LRP2 were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100. Inter-Assay: CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LRP2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LRP2 purchase    MBS2023773 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Low Density Lipoprotein Receptor Related Protein 2 (LRP2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2-2,000pg/mL in biological research samples containing LRP2, with an estimated sensitivity of 14.2pg/mL. The ELISA analytical biochemical technique of the MBS2023773 kit is based on LRP2 antibody-LRP2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LRP2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LRP2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LRP2 elisa kit

   Intended Uses: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of LRP2 in human serum, plasma and other biological fluids.

Principle of the Assay: The microplate provided in this kit has been pre-coated with an antibody specific to LRP2. Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to LRP2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain LRP2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm 10nm. The concentration of LRP2 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Product Categories/Family for LRP2 elisa kit    Metabolic pathway
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 Typical Testing Data/Standard Curve (for reference only) of LRP2 elisa kit    LRP2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2023773. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LRP2. It may not necessarily be applicable to this product.
 NCBI GI #    126012573
 NCBI GeneID    4036
 NCBI Accession #    NP_004516.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004525.2 [Other Products]
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 UniProt Primary Accession #    P98164 [Other Products]
 UniProt Secondary Accession #    O00711; Q16215 [Other Products]
 UniProt Related Accession #    P98164 [Other Products]
 Molecular Weight    521,958 Da
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 NCBI Official Full Name    low-density lipoprotein receptor-related protein 2
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein 2
 NCBI Official Symbol    LRP2 [Similar Products]
 NCBI Official Synonym Symbols   
DBS; GP330
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor-related protein 2
 UniProt Protein Name    Low-density lipoprotein receptor-related protein 2
 UniProt Synonym Protein Names   
Glycoprotein 330; gp330; Megalin
 Protein Family    Low-density lipoprotein receptor-related protein
 UniProt Gene Name    LRP2 [Similar Products]
 UniProt Synonym Gene Names    LRP-2; gp330 [Similar Products]
 UniProt Entry Name    LRP2_HUMAN
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 NCBI Summary for LRP2    The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
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 UniProt Comments for LRP2    LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: Golgi apparatus; endocytic vesicle; brush border membrane; lysosomal membrane; endoplasmic reticulum; lysosome; apical plasma membrane; integral to membrane; plasma membrane; coated pit; receptor complex; endosome

Molecular Function: protein binding; calcium ion binding; SH3 domain binding

Biological Process: steroid metabolic process; cell proliferation; receptor-mediated endocytosis; phototransduction, visible light; forebrain development; protein amino acid glycosylation; endocytosis; lipid metabolic process; retinoid metabolic process; vitamin D metabolic process

Disease: Donnai-barrow Syndrome
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 Research Articles on LRP2    1. A new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRP2 elisa kitPathways associated with LRP2 elisa kit
 Reference Product  PubMed Publications
 SHH elisa kit  >4 publications with LRP2 and SHH
 DAB2 elisa kit  >3 publications with LRP2 and DAB2
 CUBN elisa kit  >3 publications with LRP2 and CUBN
 LRPAP1 elisa kit  >2 publications with LRP2 and LRPAP1
 ALB elisa kit  >1 publications with LRP2 and ALB
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram
Diseases associated with LRP2 elisa kitOrgans/Tissues associated with LRP2 elisa kit
 Disease Name  Pubmed Publications
 Proteinuria Antibodies  >16 publications with LRP2 and Proteinuria
 Kidney Diseases Antibodies  >13 publications with LRP2 and Kidney Diseases
 Disease Models, Animal Antibodies  >11 publications with LRP2 and Disease Models, Animal
 Hearing Loss, Sensorineural Antibodies  >7 publications with LRP2 and Hearing Loss, Sensorineural
 Weight Loss Antibodies  >7 publications with LRP2 and Weight Loss
 Hernia, Diaphragmatic Antibodies  >6 publications with LRP2 and Hernia, Diaphragmatic
 Donnai-Barrow syndrome Antibodies  >5 publications with LRP2 and Donnai-Barrow syndrome
 Cardiovascular Diseases Antibodies  >5 publications with LRP2 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with LRP2 and Inflammation
 Fibrosis Antibodies  >4 publications with LRP2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >41 publications with LRP2 and Kidney
 Brain Antibodies  >27 publications with LRP2 and Brain
 Eye Antibodies  >8 publications with LRP2 and Eye
 Liver Antibodies  >6 publications with LRP2 and Liver
 Embryonic Tissue Antibodies  >6 publications with LRP2 and Embryonic Tissue
 Thyroid Antibodies  >4 publications with LRP2 and Thyroid
 Spinal Cord Antibodies  >3 publications with LRP2 and Spinal Cord
 Muscle Antibodies  >2 publications with LRP2 and Muscle
 Skin Antibodies  >1 publications with LRP2 and Skin
 Lung Antibodies  >1 publications with LRP2 and Lung
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