NP_002336.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,429 Da
NCBI Official Full Name
lumican
NCBI Official Synonym Full Names
lumican
NCBI Official Synonym Symbols
NCBI Protein Information
lumican
UniProt Protein Name
Lumican
UniProt Synonym Protein Names
Keratan sulfate proteoglycan lumican; KSPG lumican
UniProt Synonym Gene Names
UniProt Entry Name
LUM_HUMAN
NCBI Summary for LUM
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
UniProt Comments for LUM
LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q21.33
Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix
Molecular Function: collagen binding; extracellular matrix structural constituent; protein binding
Biological Process: axonogenesis; carbohydrate metabolic process; cartilage development; collagen fibril organization; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; keratan sulfate catabolic process; keratan sulfate metabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor-beta1 production; response to organic cyclic substance; visual perception
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Products associated with LUM elisa kit
Pathways associated with LUM elisa kit
Diseases associated with LUM elisa kit
Organs/Tissues associated with LUM elisa kit
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