AAA59536.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lysozyme (EC 3.2.1.17)
NCBI Official Synonym Full Names
lysozyme
NCBI Official Synonym Symbols
NCBI Protein Information
lysozyme C; 1,4-beta-N-acetylmuramidase C; c-type lysozyme
UniProt Protein Name
Lysozyme C
UniProt Synonym Protein Names
1,4-beta-N-acetylmuramidase C
UniProt Synonym Gene Names
UniProt Entry Name
LYSC_HUMAN
NCBI Summary for LYZ
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
UniProt Comments for LYZ
LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.
Protein type: Endoplasmic reticulum; Secreted, signal peptide; EC 3.2.1.17; Secreted; Hydrolase; Vesicle
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: extracellular space; extracellular region
Molecular Function: identical protein binding; lysozyme activity
Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response
Disease: Amyloidosis, Familial Visceral
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Products associated with LYZ elisa kit
Pathways associated with LYZ elisa kit
Diseases associated with LYZ elisa kit
Organs/Tissues associated with LYZ elisa kit
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