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LOX elisa kit :: Human Lysyl Oxidase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS766044
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $280 +1 FREE 8GB USB
96-Strip-Wells  /  $375 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,015 +3 FREE 8GB USB
15x96-Strip-Wells  /  $4,285 +5 FREE 8GB USB
25x96-Strip-Wells  /  $6,715 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lysyl Oxidase (LOX), ELISA Kit

★Popular Item★
 Also Known As   

Human Lysyl Oxidase ELISA Kit

 Product Synonym Names    LOX/Protein-Lysine 6-Oxidase/MGC105112/Lysyl oxidase
 Product Gene Name   

LOX elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS766044 COA    COA PDF
 OMIM    153455
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of LOX. No significant cross-reactivity or interference between LOX and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates and other biological fluids
 Detection Range    0.625-40ng/ml
 Sensitivity    <0.375ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level LOX were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level LOX were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LOX elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LOX purchase    MBS766044 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lysyl Oxidase (LOX) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625-40ng/ml in biological research samples containing LOX, with an estimated sensitivity of <0.375ng/ml. The ELISA analytical biochemical technique of the MBS766044 kit is based on LOX antibody-LOX antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LOX antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LOX. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LOX elisa kit

   Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti- LOX antibody was pre-coated onto 96-well plates. And the biotin conjugated anti- LOX antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the LOX amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of LOX can be calculated.
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 Typical Testing Data/Standard Curve (for reference only) of LOX elisa kit    LOX elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS766044. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.
 NCBI GI #    257065
 NCBI GeneID    4015
 NCBI Accession #    AAB23549.1 [Other Products]
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 UniProt Secondary Accession #    Q5FWF0; B2R5Q3 [Other Products]
 UniProt Related Accession #    P28300 [Other Products]
 Molecular Weight    46,944 Da
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 NCBI Official Full Name    lysyl oxidase
 NCBI Official Synonym Full Names    lysyl oxidase
 NCBI Official Symbol    LOX [Similar Products]
 NCBI Protein Information    protein-lysine 6-oxidase
 UniProt Protein Name    Protein-lysine 6-oxidase
 UniProt Synonym Protein Names   
Lysyl oxidase
 Protein Family    Lysyl oxidase
 UniProt Gene Name    LOX [Similar Products]
 UniProt Entry Name    LYOX_HUMAN
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 NCBI Summary for LOX    This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. [provided by RefSeq, Nov 2015]
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 UniProt Comments for LOX    LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.

Protein type: Oxidoreductase; Secreted; EC 1.4.3.13; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix

Molecular Function: copper ion binding; protein binding; protein-lysine 6-oxidase activity

Biological Process: collagen fibril organization; elastic fiber assembly; extracellular matrix organization and biogenesis; heart development; lung development; protein modification process; response to drug; response to steroid hormone stimulus; wound healing

Disease: Cutis Laxa, Autosomal Recessive, Type Ia
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 Research Articles on LOX    1. these results corroborate the role of LOX in the migration, invasion and angiogenesis of astrocytomas. Furthermore, LOX expression is influenced by IDH1 mutational status.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LOX elisa kitPathways associated with LOX elisa kit
 Reference Product  PubMed Publications
 LOXL1 elisa kit  >59 publications with LOX and LOXL1
 SRC elisa kit  >32 publications with LOX and SRC
 FGF2 elisa kit  >14 publications with LOX and FGF2
 BMP1 elisa kit  >8 publications with LOX and BMP1
 FBLN5 elisa kit  >8 publications with LOX and FBLN5
 SNAI1 elisa kit  >1 publications with LOX and SNAI1
 EFEMP2 elisa kit  >1 publications with LOX and EFEMP2
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with LOX elisa kitOrgans/Tissues associated with LOX elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >664 publications with LOX and Inflammation
 Cardiovascular Diseases Antibodies  >623 publications with LOX and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >422 publications with LOX and Disease Models, Animal
 Necrosis Antibodies  >250 publications with LOX and Necrosis
 Heart Diseases Antibodies  >192 publications with LOX and Heart Diseases
 Neoplasms, Experimental Antibodies  >157 publications with LOX and Neoplasms, Experimental
 Hypertension Antibodies  >153 publications with LOX and Hypertension
 Fibrosis Antibodies  >150 publications with LOX and Fibrosis
 Lung Neoplasms Antibodies  >131 publications with LOX and Lung Neoplasms
 Breast Neoplasms Antibodies  >119 publications with LOX and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >773 publications with LOX and Vascular
 Muscle Antibodies  >422 publications with LOX and Muscle
 Brain Antibodies  >394 publications with LOX and Brain
 Lung Antibodies  >304 publications with LOX and Lung
 Heart Antibodies  >282 publications with LOX and Heart
 Liver Antibodies  >260 publications with LOX and Liver
 Bone Antibodies  >249 publications with LOX and Bone
 Skin Antibodies  >186 publications with LOX and Skin
 Kidney Antibodies  >174 publications with LOX and Kidney
 Embryonic Tissue Antibodies  >162 publications with LOX and Embryonic Tissue
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