AAB23549.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,944 Da
NCBI Official Full Name
lysyl oxidase
NCBI Official Synonym Full Names
lysyl oxidase
NCBI Protein Information
protein-lysine 6-oxidase
UniProt Protein Name
Protein-lysine 6-oxidase
UniProt Synonym Protein Names
Lysyl oxidase
UniProt Entry Name
LYOX_HUMAN
NCBI Summary for LOX
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. [provided by RefSeq, Nov 2015]
UniProt Comments for LOX
LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.
Protein type: Oxidoreductase; Secreted; EC 1.4.3.13; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix
Molecular Function: copper ion binding; protein binding; protein-lysine 6-oxidase activity
Biological Process: collagen fibril organization; elastic fiber assembly; extracellular matrix organization and biogenesis; heart development; lung development; protein modification process; response to drug; response to steroid hormone stimulus; wound healing
Disease: Cutis Laxa, Autosomal Recessive, Type Ia
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Products associated with LOX elisa kit
Pathways associated with LOX elisa kit
Diseases associated with LOX elisa kit
Organs/Tissues associated with LOX elisa kit
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