NP_005950.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
40,188 Da
NCBI Official Full Name
melatonin receptor type 1B
NCBI Official Synonym Full Names
melatonin receptor 1B
NCBI Protein Information
melatonin receptor type 1B; mel1b receptor; melatonin receptor MEL1B
UniProt Protein Name
Melatonin receptor type 1B
UniProt Synonym Gene Names
UniProt Entry Name
MTR1B_HUMAN
NCBI Summary for MT2
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
UniProt Comments for MT2
MTNR1B: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q21-q22
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; melatonin receptor activity
Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; regulation of insulin secretion
Disease: Diabetes Mellitus, Noninsulin-dependent
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Products associated with MT2 elisa kit
Pathways associated with MT2 elisa kit
Diseases associated with MT2 elisa kit
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