NP_001012333.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,512 Da
NCBI Official Full Name
midkine isoform a
NCBI Official Synonym Full Names
midkine (neurite growth-promoting factor 2)
NCBI Protein Information
midkine; retinoic acid inducible factor; amphiregulin-associated protein; midgestation and kidney protein; neurite outgrowth-promoting factor 2
UniProt Protein Name
Midkine
UniProt Synonym Protein Names
Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein
UniProt Synonym Gene Names
UniProt Entry Name
MK_HUMAN
NCBI Summary for MK
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Comments for MK
MDK: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Belongs to the pleiotrophin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cell projection; cytoplasm; extracellular region
Molecular Function: heparin binding; growth factor activity
Biological Process: response to drug; nervous system development; cell migration; Notch signaling pathway; behavioral fear response; dentate gyrus development; short-term memory; cerebellar granular layer development; adrenal gland development; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; signal transduction; positive regulation of cell division; response to wounding; negative regulation of neuron apoptosis; cerebral cortex development; cell differentiation; defecation; regulation of behavior
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Products associated with MK elisa kit
Pathways associated with MK elisa kit
Diseases associated with MK elisa kit
Organs/Tissues associated with MK elisa kit
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