AAC50618.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,446 Da
NCBI Official Full Name
mutY homolog
NCBI Official Synonym Full Names
mutY DNA glycosylase
NCBI Official Synonym Symbols
NCBI Protein Information
adenine DNA glycosylase
UniProt Protein Name
Adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Synonym Gene Names
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
UniProt Comments for MUTYH
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Research Articles on MUTYH
Precautions
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Products associated with MUTYH elisa kit
Pathways associated with MUTYH elisa kit
Diseases associated with MUTYH elisa kit
Organs/Tissues associated with MUTYH elisa kit
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