AAA17411.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,584 Da
NCBI Official Full Name
N-ethylmaleimide-sensitive factor, partial
NCBI Official Synonym Full Names
N-ethylmaleimide-sensitive factor
NCBI Official Synonym Symbols
NCBI Protein Information
vesicle-fusing ATPase
UniProt Protein Name
Vesicle-fusing ATPase
UniProt Synonym Protein Names
N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Vesicular-fusion protein NSF
UniProt Synonym Gene Names
UniProt Entry Name
NSF_HUMAN
UniProt Comments for NSF
NSF: required for intracellular membrane fusion and vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns.
Protein type: Autophagy; Vesicle; EC 3.6.4.6; Adaptor/scaffold; Protease
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: Golgi stack; lysosomal membrane; cytoplasm; postsynaptic density; plasma membrane; dendritic shaft; cytosol
Molecular Function: protein binding; metal ion binding; ATPase activity; syntaxin-1 binding; protein complex binding; ATPase activity, coupled; protein kinase binding; Rab GTPase binding; ATP binding; PDZ domain binding
Biological Process: regulation of exocytosis; vesicle-mediated transport; synaptic transmission; intra-Golgi vesicle-mediated transport; exocytosis; metabolic process; Golgi to plasma membrane protein transport; Golgi vesicle docking; positive regulation of receptor recycling; potassium ion transport; plasma membrane fusion
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Products associated with NSF elisa kit
Pathways associated with NSF elisa kit
Diseases associated with NSF elisa kit
Organs/Tissues associated with NSF elisa kit
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