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NAGS elisa kit :: Human N-acetylglutamate synthase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9327797 NAGS elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N-acetylglutamate synthase (NAGS), ELISA Kit

 Also Known As   

Human N-acetylglutamate synthase, mitochondrial, NAGS ELISA Kit

 Product Synonym Names    Human N-acetylglutamate synthase; mitochondrial (NAGS) ELISA kit; AGAS; ARGA; MGC133025; ; N-acetylglutamate synthase
 Product Gene Name   

NAGS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    608300
 3D Structure    ModBase 3D Structure for Q8N159
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of NAGS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NAGS purchase    MBS9327797 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the N-acetylglutamate synthase (NAGS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NAGS. The ELISA analytical biochemical technique of the MBS9327797 kit is based on NAGS antibody-NAGS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NAGS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NAGS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for NAGS. It may not necessarily be applicable to this product.
 NCBI GI #    23308587
 NCBI GeneID    162417
 NCBI Accession #    NP_694551.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_153006.2 [Other Products]
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 UniProt Primary Accession #    Q8N159 [Other Products]
 UniProt Secondary Accession #    Q8IWR4; B2RAZ9 [Other Products]
 UniProt Related Accession #    Q8N159 [Other Products]
 Molecular Weight    58,156 Da
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 NCBI Official Full Name    N-acetylglutamate synthase, mitochondrial
 NCBI Official Synonym Full Names    N-acetylglutamate synthase
 NCBI Official Symbol    NAGS [Similar Products]
 NCBI Official Synonym Symbols   
AGAS; ARGA
[Similar Products]
 NCBI Protein Information    N-acetylglutamate synthase, mitochondrial; amino-acid acetyltransferase
 UniProt Protein Name    N-acetylglutamate synthase, mitochondrial
 UniProt Synonym Protein Names   
Amino-acid acetyltransferaseCleaved into the following 3 chains:N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form
 Protein Family    N-acetylglutamate synthase
 UniProt Gene Name    NAGS [Similar Products]
 UniProt Entry Name    NAGS_HUMAN
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 NCBI Summary for NAGS    The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NAGS    NAGS: Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity. Defects in NAGS are the cause of N-acetylglutamate synthase deficiency (NAGSD). NAGSD is a rare autosomal recessively inherited metabolic disorder leading to severe neonatal or late onset hyperammonemia without increased excretion of orotic acid. Clinical symptoms are somnolence, tachypnea, feeding difficulties, a severe neurologic presentation characterized by uncontrollable movements, developmental delay, visual impairment, failure to thrive and hyperammonemia precipitated by the introduction of high-protein diet or febrile illness. Belongs to the acetyltransferase family.

Protein type: Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 2.3.1.1; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: mitochondrial matrix

Molecular Function: amino-acid N-acetyltransferase activity

Biological Process: glutamate metabolic process; arginine biosynthetic process; urea cycle

Disease: N-acetylglutamate Synthase Deficiency
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 Research Articles on NAGS    1. Sp1, CREB, HNF-1, and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NAGS elisa kitPathways associated with NAGS elisa kit
 Reference Product  PubMed Publications
 OTC elisa kit  >7 publications with NAGS and OTC
 ASS1 elisa kit  >3 publications with NAGS and ASS1
 GLUD1 elisa kit  >1 publications with NAGS and GLUD1
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Urea Cycle Pathway antibodies  Urea Cycle Pathway Diagram
Diseases associated with NAGS elisa kitOrgans/Tissues associated with NAGS elisa kit
 Disease Name  Pubmed Publications
 Hyperammonemia Antibodies  >40 publications with NAGS and Hyperammonemia
 Nervous System Diseases Antibodies  >24 publications with NAGS and Nervous System Diseases
 Liver Diseases Antibodies  >10 publications with NAGS and Liver Diseases
 Mental Disorders Antibodies  >5 publications with NAGS and Mental Disorders
 Fatty Liver Antibodies  >3 publications with NAGS and Fatty Liver
 Edema Antibodies  >3 publications with NAGS and Edema
 Cholestasis, Intrahepatic Antibodies  >2 publications with NAGS and Cholestasis, Intrahepatic
 Kidney Diseases Antibodies  >1 publications with NAGS and Kidney Diseases
 Hyperplasia Antibodies  >1 publications with NAGS and Hyperplasia
 Poisoning Antibodies  >1 publications with NAGS and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >43 publications with NAGS and Liver
 Blood Antibodies  >25 publications with NAGS and Blood
 Brain Antibodies  >10 publications with NAGS and Brain
 Intestine Antibodies  >6 publications with NAGS and Intestine
 Kidney Antibodies  >6 publications with NAGS and Kidney
 Prostate Antibodies  >1 publications with NAGS and Prostate
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